Results 111 to 120 of about 5,888,395 (293)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Spectral energy distributions of a large sample of BL Lacertae objects

, 2005
We have collected a large amount of multifrequency data for the objects in the Metsahovi Radio Observatory BL Lacertae sample and computed their spectral energy distributions (SED).
Bondi, Caccianiga, Caccianiga, Costamante, Donato, E. Nieppola, E. Valtaoja, Fossati, Ghisellini, Gioia, Giommi, Giommi, Giommi, Giommi, Hartman, Jannuzi, Kühr, Lamer, Landt, Laurent-Muehleisen, M. Tornikoski, Padovani, Padovani, Perlman, Perlman, Perlman, Pian, Stickel, Stickel, Stocke, Stocke, Urry, Veron-Cetty, Veron-Cetty, Veron-Cetty, Voges   +35 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Transition Detection at Cryogenic Temperatures Using a Carbon-Based Resistive Heating Layer Coupled with Temperature Sensitive Paint [PDF]

This paper will highlight the development and application of a carbon-based resistive heating layer for use in transition detection at cryogenic temperatures at the National Transonic Facility (NTF) for full-flight Reynolds number testing.
Goodman, Kyle Z., Peak, Sarah M., Watkins, A. Neal   +2 more
core   +1 more source

Peak-holding circuit for extremely narrow pulses [PDF]

, 1973
Circuit was developed which can stretch pulses in 50- to 3200-ns range to make them acceptable for pulse-height analyzers. Circuit uses high-speed wide-band amplifier, does not need excessive frequency compensation, and can handle pulses one-tenth of ...
Oneill, R. W.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Multiband Optical Variability of the Blazar OP 313 in the Outburst State during 2024–2025

The Astrophysical Journal
We present the analysis results of flux and spectral variability of the blazar OP 313 across intra-night to short-term timescales using BVRI photometric data, gathered over 25 nights from 2024 November to 2025 May, using two optical telescopes in ...
P. U. Devanand, Alok C. Gupta, Karan Dogra, Shubham Kishore, Tushar Tripathi   +4 more
doaj   +1 more source

Peak acceleration limiter for vibrational tester Patent [PDF]

, 1971
Electronic detection system for peak acceleration limits in vibrational testing of spacecraft ...
Chapman, C. P.
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source