Results 61 to 70 of about 290,122 (298)

The Influence of a Memory Delay on Spatial Coding in the Superior Colliculus: Is Visual Always Visual and Motor Always Motor?

Frontiers in Neural Circuits, 2018
The memory-delay saccade task is often used to separate visual and motor responses in oculomotor structures such as the superior colliculus (SC), with the assumption that these same responses would sum with a short delay during immediate “reactive ...
Morteza Sadeh, Morteza Sadeh, Morteza Sadeh, Morteza Sadeh, Morteza Sadeh, Amirsaman Sajad, Amirsaman Sajad, Amirsaman Sajad, Amirsaman Sajad, Hongying Wang, Hongying Wang, Xiaogang Yan, Xiaogang Yan, John Douglas Crawford, John Douglas Crawford, John Douglas Crawford, John Douglas Crawford, John Douglas Crawford   +17 more
doaj   +1 more source

The COVID-19 pandemic preparedness simulation tool: CovidSIM

BMC Infectious Diseases, 2020
Background Efficient control and management in the ongoing COVID-19 pandemic needs to carefully balance economical and realizable interventions. Simulation models can play a cardinal role in forecasting possible scenarios to sustain decision support ...
Kristan A. Schneider, Gideon A. Ngwa, Markus Schwehm, Linda Eichner, Martin Eichner   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The effects of delay to reinforcement and inter-trial interval on fixed-ratio schedule performance [PDF]

, 2013
A delay to reinforcement has been found in previous studies to influence the effectiveness of a reinforcer. As the delay duration increases, response rates decrease and post reinforcement pause durations increase.
Stuart, Stacey Louisa
core  

A delay differential equation mathematical model for the control of the hormonal system of the hypothalamus, the pituitary and the testis in man [PDF]

, 2008
In this paper we develop previously studied mathematical models of the regulation of testosterone by luteinizing hormone and luteinizing hormone release hormone in the human body. We propose a delay differential equation mathematical model which improves
, Sultan Qaboos University, Oman (Funder), Khan, Q.J.A., Greenhalgh, D., Greenhalgh, David, Khan, Qamar J. A., Khan, Qamar, Sultan Qaboos University, Oman (Funder)   +6 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Damage characteristics of surrounding rock and evolution law of rupture zone in deep roadway under dynamic loading

Meikuang Anquan
With the continuous increase of mining depth in coal mines, the occurrence of deep roadway engineering disasters induced by dynamic disturbances has become more frequent.
Jian ZHANG, Zhen LI, Xuelong LI, Yong WANG   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A Design of 6.8 mW All Digital Delay Locked Loop With Digitally Controlled Dither Cancellation for TDC in Ranging Sensor

IEEE Access, 2020
This paper presents a design of 6.8 mW all digital delay locked loop (ADDLL) with digitally controlled dither cancellation (DCDC) for time to digital converter (TDC) in ranging sensors.
Muhammad Riaz Ur Rehman, Arash Hejazi, Imran Ali, Jae Jin Lee, Seong Jin Oh, Younggun Pu, Kang-Yoon Lee   +6 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source