Results 111 to 120 of about 5,771,017 (249)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Electric peak demand reduction programs

, 2009
Title from Web page (OLR web site, viewed Dec. 22, 2009).; "December 15, 2009."; Discusses efforts to reduce electric peak demand and the extent to which they have succeeded.; Harvested from the web on 12/22 ...
McCarthy, Kevin E. (Kevin Edward), 1954-
core   +1 more source

Barber optimization algorithm for efficient load shifting and peak clipping in demand side management

Discover Energy
This paper investigates the application of the recently developed Barber Optimization Algorithm (BaOA) to demand-side management (DSM), with a focus on load shifting and peak clipping.
Abuyile Mpaka, Senthil Krishnamurthy
doaj   +1 more source

Other title: Ohio Trafficking in Persons Study Commission, Demand Reduction Sub-Committee, report on prevention and intervention to address human trafficking in Ohio

, 2010
"December 15, 2010."; Includes bibliographical references (p.
Ohio Trafficking in Persons Study Commission. Demand Reduction Sub-Committee.
core  

Changing demand: flexibility of energy practices in households with children (final report) [PDF]

, 2015
This report summarises the findings and recommendations from the ‘Changing Demand: Flexibility of energy practices in households with children’ research project funded by the Consumer Advocacy Panel.
Yolande Strengers, Larissa Nicholls
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Countercyclical Price Movements during Periods of Peak Demand: Evidence from Grocery Retail Price for Avocados [PDF]

Using a unique micro dataset and advanced panel models, this study examines the effects of demand shocks on grocery retail price for avocados, a key Californian fresh produce commodity.
Carman, Hoy F., Li, Lan, Sexton, Richard J.   +2 more
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Analysis of Peak Demand Reduction and Energy Saving in a Mixed-Use Community through Urban Building Energy Modeling

Energies
Energy saving in buildings is essential as buildings’ operational energy use constitutes 30% of global energy consumption. Urban building energy modeling (UBEM) effectively understands urban energy consumption.
Wenxian Zhao, Zhang Deng, Yanfei Ji, Chengcheng Song, Yue Yuan, Zhiyuan Wang, Yixing Chen   +6 more
doaj   +1 more source

Peak Demand Impacts From Electricity Efficiency Programs [PDF]

, 2019
Quantification of the costs and benefits of electricity efficiency programs have focused largely on the economic value of annual energy reductions. State public utility commissions PUCs and utilities are increasingly interested in assessing peak demand ...
Leventis, Greg, Frick, Natalie Mims, Schwartz, Lisa C, Hoffman, Ian M, Goldman, Charles A, Murphy, Sean   +5 more
core