Results 61 to 70 of about 6,190,215 (306)

The Influence of Air-Conditioning Efficiency in the Peak Load Demand for Kuwait [PDF]

open access: yes, 2007
A model co-relating the peak load demand of a utility with the allowable power rating (PR) of air-conditioning (AC) systems has been developed in this paper through a well defined methodology.
Maheshwari, G. P., Ali, A. A.
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Concurrent validity of Myotest for assessing explosive strength indicators in countermovement jump

open access: yesActa Gymnica, 2018
Background: Previous research has determined the validity and reliability of accelerometer-based devices, but the findings are not consistent. Objective: The purpose of this study was to determine the validity of an accelerometer (Myotest PRO) for ...
Vladimír Hojka   +7 more
doaj   +1 more source

Peak Shift in Remembering [PDF]

open access: yes, 2003
If remembering is discriminative behaviour along the dimension of time and if, as Sargisson and White (2001) argued, generalisation around a peak can occur in this behaviour, then the peak shift which has been shown in discrimination along so many other ...
Hoan, Andros
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Relationship Between Lower-Body Power and Sport-Specific Start Performance in International-Level BMX Riders

open access: yesJournal of Functional Morphology and Kinesiology
Background: Bicycle Motocross (BMX) performance is strongly influenced by the start phase, which requires rapid force and power production to achieve optimal race posi-tioning; however, the relationship between lower-body power and sport-specific start ...
Noel Marcen-Cinca   +2 more
doaj   +1 more source

Effects of different rest intervals in high intensity interval training programs on VO2max, body composition, and isokinetic strength and power [PDF]

open access: yesJournal of Men's Health
The aim of this study was to evaluate the effect of 8 weeks of short and long rest running-based high-intensity training (HIIT) on body composition, isokinetic strength, and maximal oxygen uptake (VO2max). Nineteen physically active men were recruited
Recep Fatih Kayhan   +8 more
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

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