Results 141 to 150 of about 9,418 (281)

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source

The Geography of Success: A Spatial Analysis of Export Intensity in the Italian Wine Industry

Agribusiness, EarlyView.
ABSTRACT This paper investigates the paradox of how Italy's fragmented, SME‐dominated wine industry achieves global export success. Moving beyond purely firm‐centric explanations, we test whether export intensity is spatially dependent, clustering geographically in regional ecosystems.
Nicolas Depetris Chauvin, Jonas Di Vita
wiley   +1 more source

Assessing the reliability of saw mark features: A comparative study using stereomicroscopy, micro-XCT, and 3D printing. [PDF]

J Forensic Sci
de Wet PD, Ridel AF, Hagg AC, Hoffman JW, L'Abbé EN.   +4 more
europepmc   +1 more source

Peak-load shaving in smart homes via online scheduling

This paper addresses the problem of load-shaving in Smart Homes in view of improving energy efficiency in Smart Grids. An architecture of home power management systems, allowing the separation of domestic power load control from grid dynamics, is ...
Kheir, Jan, Costanzo, Giuseppe, Zhu, Guchuan   +2 more
core   +1 more source

Application of Neural Networks for Advanced Ir Spectroscopy Characterization of Ceria Catalysts Surfaces

Advanced Intelligent Discovery, EarlyView.
A novel convolutional neural network architecture enables rapid, unsupervised analysis of IR spectroscopic data from DRIFTS and IRRAS. By combining synthetic data generation with parallel convolutional layers and advanced regularization, the model accurately resolves spectral features of adsorbed CO, offering real‐time insights into ceria surface ...
Mehrdad Jalali, Lachlan Caulfield, Eric Sauter, Alexei Nefedov, Chengwu Yang, Christof Wöll   +5 more
wiley   +1 more source

A Refined Short-term Scheduling Method Considering the Difference of Peak-shaving Performance of Hydropower Stations

Renmin Zhujiang
The scale of regulated hydropower in the power grid and the demand for refined dispatch continue to expand.How to carry out refined peak-shaving considering the differences in the regulatory performance of different power stations,which makes thermal ...
HUANG Kui, CHENG Ruixiang, HU Jiaqiu, LI Xiangyang, ZHU Yunke, WU Xinyu   +5 more
doaj  

Bilevel Internal Model Control-Desired Dynamic Equation-PID Control Strategy for Superheated Steam Regulation in Combined Heat and Power unit. [PDF]

ACS Omega
Zhao J, Dai C, Li D, Ding Y, Tian B, Yan G, Xue Y.   +6 more
europepmc   +1 more source

Talk to Your Data: An Agentic Artificial Intelligence‐Driven Decision‐Support Framework for Prosumer Energy Optimization and Recommendations

Advanced Intelligent Systems, EarlyView.
An agentic AI‐driven decision‐support framework for prosumers is proposed, integrating PV generation, load profiling, and multihorizon optimization within a four‐agent architecture. The approach significantly reduces grid dependence, enhances self‐sufficiency and prevents system oversizing.
Adela BÂRA, Simona‐Vasilica OPREA
wiley   +1 more source

The peak shifting electricity consumption management and influencing factors of smart grid from recurrent neural network model and deep learning. [PDF]

Sci Rep
Wang F, Huang D, Lu W.
europepmc   +1 more source