Results 41 to 50 of about 146,243 (276)

How Advanced Artificial Intelligence Technologies Shape Drug–Drug and Drug–Target Interaction Modeling

Advanced Science, EarlyView.
This review explores the convergence of artificial intelligence technologies in modeling drug–drug and drug–target interactions. By evaluating advanced feature engineering, architectural innovations, and learning paradigms reveals shared evolutionary trends and critical challenges, such as cold‐start settings and shortcut learning.
Xin Sun, Tong Wang
wiley   +1 more source

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source

Research of Optimal Experiment on Bridge Pier Types for Reducing Backwater

MATEC Web of Conferences, 2015
There are many kinds of commonly-used bridge pier types. This paper researches the selection principle and optimal type of the bridge pier types from the perspective of reducing backwater.
He Zhenjun, Zhang Jinming, He Yong, Mu Shousheng   +3 more
doaj   +1 more source

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity

Advanced Science, EarlyView.
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li, Xin‐Yuan Zhao, Min Zhang, Zhuang‐Feng Weng, Xiao‐Ran Guo, Ying‐Fang Liu, Qiao‐Ping Wang, Huan‐Huan Liang   +7 more
wiley   +1 more source

EU PEARL PaCEPT Supplementary

, 2023
This repository contains supplementary files to our paper describing the background and use of the EU PEARL Patient and Community Engagement Platform: https://patientengagement.synapseconnect.org/initiatives/eu-pearl-patient-and-community-engagement-in ...
EU PEARL Consortium, Hannes Jarke
core   +1 more source

Interfacial Proton‐Relay Microenvironment Enables Self‐Driven Singlet Oxygen Generation under Neutral Conditions

Advanced Science, EarlyView.
An interfacial proton‐relay microenvironment at MoS2‐CuCl heterostructures enables selective O2 activation to 1O2 under neutral conditions. Electron‐deficient sulfur sites mediate proton transfer to Cu‐bound O2, accelerating *OOH hydrogenation while suppressing O─O bond cleavage, achieving stable, efficient pollutant removal.
Qiaoyu Gao, Xiaohui Dai, Jian Ye, Lili Li, Chenxiao Yu, Yuehan Jiang, Jiangdong Dai, Xiaohua Tian, Jun Zhao, Jianming Pan   +9 more
wiley   +1 more source

Biomimetic Macrophage Cell Membrane‐Based Nanoparticles for Effective Treatment of Glioblastoma Through Boron Neutron Capture Therapy Combined With Immunotherapy

Advanced Science, EarlyView.
ABSTRACT Glioblastoma multiforme (GBM) remains largely incurable due to the blood‐brain barrier (BBB) and immunosuppressive microenvironment. While boron neutron capture therapy (BNCT) selectively eradicates tumor cells via 10B(n, α)‐7Li reactions, its clinical potential in GBM is unrealized because of the suboptimal pharmacokinetics of conventional ...
Jiawen Chen, Haoyu You, Hefa Huang, Huihui Chai, Ruize Zhu, Yun Guan, Qisheng Tang, Tianwen Li, Shan Jiang, Houshi Xu, Peng Wang, Yue Wang, Maoyuan Sun, Beining Liu, Zhen Li, Yulai Zeng, Weiqiu Ping, Yanlin Teng, Songlin Yan, Qinghui Li, Long Gu, Tao Sun, Zhifeng Shi   +22 more
wiley   +1 more source

Flume experimental study on evolution of a mouth bar under interaction of floods and waves

Water Science and Engineering, 2019
Based on the characteristics of hydrodynamics and sediment transport in the bar area in the Modaomen Estuary, a flume experiment was performed to study the evolution of the longitudinal profile of the mouth bar.
Li Yan, Men-wu Wu, Ying Chen, Yao Wu, Tian-sheng Wu   +4 more
doaj   +1 more source

Heterogeneous Knitted Fabrics for 3D Flexible Capacitive Sensors With Enhanced Sensitivity and Durability

Advanced Electronic Materials, EarlyView.
A breathable textile capacitive pressure sensor based on heterogeneous double‐sided conductive knitted fabrics and a spacer dielectric layer is developed. Structural tuning of the spacer thickness enables optimized compressibility and enhanced pressure sensitivity.
Wei Ke, Jinchun Liu, Yingying Wang, Yan Huang, Zhao Li, Ming Yang, Sakil Mahmud   +6 more
wiley   +1 more source

Infestation of the pearl oysters by the boring and fouling organisms in the northern coast of Persian Gulf

‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 1995
Infestation of the pearl oysters Pinctada margatifera and Pinctada fucata b the boring and fouling organisms at pearl culture farms as well as in the wild were studied in the northern coast of Persian Gulf Barnacles, spat of edible oysters and ...
M. Saveh dorodi
doaj