Results 61 to 70 of about 779,309 (276)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Application-Level Caching Approach Based on Enhanced Aging Factor and Pearson Correlation Coefficient

open access: yesJOIV: International Journal on Informatics Visualization
Relational database management systems (RDBMS) have long served as the fundamental infrastructure for web applications. Relatively slow access speeds characterize an RDBMS because its data is stored on a disk. This RDBMS weakness can be overcome using an
Mulki Indana Zulfa   +4 more
doaj   +1 more source

Modeling Water Quality Parameters Using Data-driven Methods

open access: yesمجله آب و خاک, 2017
Introduction: Surface water bodies are the most easily available water resources. Increase use and waste water withdrawal of surface water causes drastic changes in surface water quality.
Shima Soleimani   +2 more
doaj   +1 more source

Outlier Filtering for Identification of Gene Regulations in Microarray Time-Series Data [PDF]

open access: yes
[[abstract]]Microarray technology provides an opportunity for scientists to analyze thousands of gene expression profiles simultaneously. Time-series microarray data are gene expression values generated from microarray experiments within certain time ...
[[alternative]]許輝煌, Yang, Andy C.
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

THE USE OF ICT IN RELATION TO THE PARAGRAPH WRITING ACHIEVEMENT OF ENGLISH EDUCATION STUDY PROGRAM STUDENTS AT SRIWIJAYA UNIVERSITY

open access: yesEnglish Community Journal, 2020
Technology has spread throughout the world and has been used by the world community in the 21st century era. The use of technology is integrated into almost all aspects of human life, including education in paragraph writing.
Melisa Kristina Simamora   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

The Correlations of Advertising Exposure, Communication Competency of Ambassador, and Intensity of Peer Group Communication with Decision of Using Telkomsel Product [PDF]

open access: yes, 2016
Competition between cellular provider products in Indonesia is getting tougher. In order to maintain the existence and expanding market in the youth segment, Telkomsel do some marketing strategies like advertising in mass media and holding Ambassador ...
Herieningsih, MS, Dra. Sri Widowati   +1 more
core  

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