Results 121 to 130 of about 123,863 (280)
Advanced Science, EarlyView.This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao +8 more
wiley +1 more source
DADA Enhances CD8+ T Cell Stemness to Improve Anti‐Tumor Immunity and Immunotherapy Efficacy
Advanced Science, EarlyView.Diisopropylamine dichloroacetate (DADA) enhances CD8+ T cell stemness by improving OXPHOS and mitochondrial fitness in a PDK1‐depenpendent manner. This metabolic shift strengthens CD8+ T cell anti‐tumor immunity, improves responses to PD‐1 blockade, and endows CAR‐T cells with prolonged persistence and resistance to terminal exhaustion, highlighting a ...
Mingyue Bi +12 more
wiley +1 more source
ASPECTS OF THE COOPERATIVE MOVEMENT IN NORTH AFRICA [PDF]
Agribusiness,
Brown, Donald G.
core +1 more source
Macrophage Extracellular Traps in Immunity and Cancer
Advanced Science, EarlyView.As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li +5 more
wiley +1 more source
Traditional Wrestling in Niger: Between state voluntarism and ancestral symbolism
Tydskrif vir Letterkunde, 2019 Traditional wrestling occupies pride of place in Niger, compared to other sports and cultural activities. Interest in traditional wrestling is widespread among Nigériens from all walks of life: young men, adults, senior citizens, young women, mature ...
Mahaman L. Sériba
doaj
Advanced Science, EarlyView.We introduce a novel, ion‐targeted strategy to enhance calcium permeation in voltage gated calcium channels. By directly driving the ions’ coherent collective motion via resonant coupling with a 1.65 THz field, we lower the inter‐site energy barrier, inducing a statistically significant enhancement of ion influx.
Zihao Zhang +6 more
wiley +1 more source
Advanced Science, EarlyView.Schematic illustration of the synthesis protocol for Fe‐SH@Fn, an AML‐targeted nanoplatform engineered to co‐deliver shikonin (SH) and Fe3+, synergistically boosting antitumor immunity via ferroptosis induction and immunogenic cell death (ICD). ABSTRACT Acute myeloid leukemia (AML) remains a therapeutic challenge due to its low immunogenicity and ...
Shangqin Yang +9 more
wiley +1 more source
Advanced Science, EarlyView.Based on allantoin‐loaded ZIF8 nanoparticles (Alla@ZIF8) and methacrylated quaternary ammonium carboxymethyl chitosan/resveratrol composite hydrogels (RMQCC), an adaptive multifunctional hydrogel system (Alla@ZIF8‐Gel) was constructed and confirmed to induce the healing of MRSA‐infected wounds via suppressing bacterial proliferation, alleviating ...
Yongjie Zhu +8 more
wiley +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Advanced Science, EarlyView.A cation‐anion synergistic strategy is developed to enhance self‐assembled monolayer (SAM) adsorption using guanidinium thiocyanate (GuaSCN). Guanidinium (Gua⁺) suppresses micelle aggregation, while thiocyanate (SCN−) promotes phosphonic acid deprotonation and strengthens ionic bonding to the substrate.
Haofan Ma +16 more
wiley +1 more source