A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang +15 more
wiley +1 more source
Prevalence and factors associated with unsafe abortion among married women admitted to the gynecology ward at Lira regional referral hospital in Lira City Northern Uganda. [PDF]
Omiat DD +6 more
europepmc +1 more source
Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou +22 more
wiley +1 more source
Emerging migrant workers and aspiring capitalist farmers in the aftermath of the land rush in Ethiopia. [PDF]
Belay M.
europepmc +1 more source
Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang +16 more
wiley +1 more source
From translocalization to commuterization: Chinese migrant factory workers' changing arrangements of welfare and care. [PDF]
Tian Y.
europepmc +1 more source
Economic Transition: A Movement of the People or the Leader? [PDF]
Berthel, Kyle, Berthel, Kyle
core +1 more source
Paving the Way to Elucidate Hg's Role in Tumorigenesis
Tumorigenesis can result from diverse environmental carcinogens. Among them, mercury—a lifelong bioaccumulative Group 2B carcinogen—has tumorigenic potential that remains poorly understood due to confounding co‐exposures and limited organ‐specific data.
Shouying Li +10 more
wiley +1 more source
Obstetric complications and socio-demographic characteristics associated with severe maternal morbidity at Mbeya Zonal Referral Hospital, Tanzania: a case-control study. [PDF]
Mbogoro EJ, Senga M, Mokeha R.
europepmc +1 more source

