Results 161 to 170 of about 25,837 (278)

First achievement of high-confinement mode in proton-boron plasmas. [PDF]

Innovation (Camb)
Wang Y, Shi Y, Guo D, Zhao Y, Yang G, Wang A, Li H, Song S, Yuan Y, Zhang X, Gu X, Zhang C, Li J, Li S, Tao R, Huang X, Zhang Y, Wang Z, Xie Q, Li L, Han L, Zhao X, Xie H, Song X, Dong J, Peng YM, Liang Y, Liu M, EXL-50U Team.   +28 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Taming harmful bursts and heat flux in high-confinement tokamak plasmas. [PDF]

Nat Commun
Hu QM, Wang HQ, Navarro M, Wang HH, Eldon D, Gu S, Ma XX, Frerichs H, Scotti F, Wang L, Wilcox RS, Wilks TM, Bortolon A, Ceelen L, Effenberg F, Gong XZ, Jia MN, Kim SK, Lasnier CJ, Leonard AW, Li KD, Logan NC, Ma Q, Maingi R, Meng LY, Moser AL, Osborne TH, Paz-Soldan C, Shafer MW, Sun YW, Yang SM, Ye C.   +31 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Absolute scaling of small- and wide-angle X-ray scattering images recorded with short duration X-ray pulses on a large area fiber-taper X-ray detector. [PDF]

J Synchrotron Radiat
Cho HS, Schotte F, Henning R, Anfinrud PA.   +3 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Pedestal Conditions for Small ELM Regimes in Tokamaks [PDF]

, 2006
West, W. P., Hughes, J. W., Hubbard, A., Maingi, R., Hughes, J., Horton, L., ITPA Pedestal Topical Group, West, W., Oyama, N., Hubbard, A. E., Suttrop, W., Gohil, P., Kamada, Y., Loarte, A., Horton, L. D., Stober, J., Leonard, A. W., Sartori, R., Stober, J. K., Kamiya, K., Leonard, A., Saibene, G., Urano, H.   +22 more
core  

Pattern Fidelity of Vertically Aligned GaAs Nanowire Arrays. [PDF]

Small
Koch J, Qiu J, Bohlemann CY, Ostheimer D, Zhao H, Kleinschmidt P, Lei Y, Hannappel T.   +7 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Phage-encoded sRNA counteracts xenogeneic silencing in pathogenic E. coli. [PDF]

PLoS Pathog
Poudyal P, Sy B, Mediati DG, Payne M, Nandel V, Norris D, McAteer S, Ullah A, Li S, Menz L, Alquethamy S, Scadden J, Ridone P, Waters S, Dallman TJ, Baker M, Lan R, Gally D, Tree JJ.   +18 more
europepmc   +1 more source