Results 211 to 220 of about 69,287 (288)

A design-integrated framework for neuroarchitectural research. [PDF]

Front Psychol
Wei N, Chuquichambi EG, Damiano C, Bruce K, Walther DB.   +4 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Carbon footprint analysis and emission reduction pathways of Bogie frame manufacturing process in Urban Rail Transportation. [PDF]

Sci Rep
Zhou J, Wang R, Liu C.
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Research on Optimized Design of In Situ Dynamic Variable-Aperture Device for Variable-Spot Ion Beam Figuring. [PDF]

Micromachines (Basel)
Zou H, Hu H, Peng X, Liu M, Wang P, Guan C.   +5 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

A novel sandwich-type terahertz metasurface sensor integrated ultrathin microfluidic channel for direct detection of aqueous solutions. [PDF]

Nanophotonics
Cao Y, Sun H, Song X, Feng Z, Liang S, Chen Y, Ma L, Li L, Wu W.   +8 more
europepmc   +1 more source

EARLY-AGE CRACK IN CONCRETE IN PEDESTAL STRUCTURES OF SLEEPERS

INTERNATIONAL JOURNAL OF CIVIL ENGINEERING AND TECHNOLOGY (IJCIET), 2020
openaire   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A new methodology for sub-femtomolar detection of organic molecules through the combination of surface-enhanced Raman spectroscopy and a superhydrophobic fluidic concentrator. [PDF]

Anal Sci Adv
Fabre V, Carcenac F, Laborde A, Doucet JB, Vieu C, Louarn P, Trevisiol E.   +6 more
europepmc   +1 more source