Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes
Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang +14 more
wiley +1 more source
A Qualitative Analysis of Vehicle Positioning Requirements for Connected Vehicle Applications [PDF]
Barth, Matthew, Williams, Nigel
core
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang +21 more
wiley +1 more source
Deformation Driven Suction Cups: A Mechanics‐Based Approach to Wearable Electronics
Deformation‐driven suction cups enable robust, reversible adhesion of wearable electronics to human skin spanning wide mechanical compliance, without adhesives or tight straps. By integrating mechanics modeling, experiments, and contact mechanics theory, this work reveals how cup geometry, substrate compliance, and interfacial adhesion govern suction ...
Seola Lee +10 more
wiley +1 more source
SHAKF-PU: Sage-Husa Adaptive Kalman Filtering-Based Pedestrian Characteristic Parameter Update Mechanism for Enhancing Step Length Estimation in Pedestrian Dead Reckoning. [PDF]
Tseng CH, Wu JY.
europepmc +1 more source
Indoor Positioning Based on Pedestrian Dead Reckoning and Magnetic Field Matching for Smartphones. [PDF]
Kuang J, Niu X, Zhang P, Chen X.
europepmc +1 more source
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei +17 more
wiley +1 more source
A Fully Self‐Powered Digital Wearable System for the Auxiliary Treatment of Plantar Fasciitis
This study reports a system‐level fully self‐powered digital wearable system (FS‐DWS) for the auxiliary treatment of plantar fasciitis. By integrating arch support, energy harvesting, wearable sensing, and machine learning‐driven closed‐loop visualized feedback, the system enables effective plantar pressure reduction and self‐powered, real‐time plantar
Jiacheng Hou +10 more
wiley +1 more source
A bioinspired piezoelectric sensor mimicking Pacinian corpuscles is developed to enable ultrasensitive and linear pressure sensing. A multilayer grooved architecture converts normal pressure into in‐plane strain, delivering high sensitivity, wide linear range, and efficient energy harvesting, enabling high‐fidelity wrist pulse monitoring and ...
Qi Yang +8 more
wiley +1 more source
Combining a Modified Particle Filter Method and Indoor Magnetic Fingerprint Map to Assist Pedestrian Dead Reckoning for Indoor Positioning and Navigation. [PDF]
Ning FS, Chen YC.
europepmc +1 more source

