A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun +12 more
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The Trauma Burden of Electric Scooter-Related Injuries Presenting to a Single-Centre Trauma and Orthopaedic Department in Central Birmingham. [PDF]
Begum S, Tahir M, Mostafa O, Prakash D.
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Quantum-inspired pedestrian mobility modeling: Applying probabilistic spatial simulation to urban walkability and thermal comfort in Sri Lanka. [PDF]
Deshan M, Jayasinghe A, Abenayake C.
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Estimating the clinical and financial burden of motorcycle injuries on a rural faith-based hospital in Kenya: a 9-month retrospective review. [PDF]
Mikanatha IB +4 more
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Identification of Stress Location During Low-Speed Mobility Travel Using Environmental Data. [PDF]
Jadram N, Nishikawa Y, Sugaya M.
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Perception based investigation exploring recurrence of violations by motorist and non-motorist at rail road grade crossings. [PDF]
Vivek AK, Mohapatra SS, Khan T.
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Impact of drink-driving penalty enhancement policies on road traffic injury deaths among vulnerable road users in Shandong Province: an interrupted time series study. [PDF]
Zhang Z +9 more
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