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A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

open access: yesAdvanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun   +12 more
wiley   +1 more source
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A Pedestrian-Pedestrian and Pedestrian-Vehicle Interaction Motion Model for Pedestrians Tracking

2014
We propose a pedestrian-pedestrian and pedestrian-vehicle interaction motion model for predicting the motion of the pedestrians and tracking pedestrians in traffic scene mixed with cars. Pedestrians’ motion in such scenes are often complex and highly correlated with both pedestrians and vehicles nearby.
Hao Sheng 0001   +4 more
openaire   +1 more source

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