Results 131 to 140 of about 877,343 (248)

Maternal and Pediatric Precision in Therapeutic Knowledge Portal (MPRINT-KP): Landscape Analysis of Pharmacology Research in Maternal and Pediatric Patient Populations. [PDF]

Pharmacotherapy
Liu X, Shendre A, Wang L, O'Kane A, Ma H, Chiang CW, Zaidi SS, Aboshady OA, So G, Tillman EM, Kirkpatrick LM, Costantine M, Grannis S, Rogerson CM, Bartlett C, Rahurkar S, Cheng L, Ouyang J, Wei P, Zhu Z, Li S, Huang Y, Wang L, Cao W, Jiang H, Liu J, Oteng SR, Goodwin A, Deypalubos JAF, Zhang S, Bies R, Quinney SK, Li L.   +32 more
europepmc   +1 more source

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

Barriers to implementing AI in pediatric cancer imaging. [PDF]

Cancer Imaging
Gupta A, Towbin AJ.
europepmc   +1 more source

Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia

Advanced Science, EarlyView.
This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen, Chunyu Yin, Yang Yang, Yan Guo, Xingyun Wang, Rui Cheng   +14 more
wiley   +1 more source

IAPSCON 2007 Abstracts

Journal of Indian Association of Pediatric Surgeons, 2007
Indian Association of Pediatric Surgeons
doaj  

Systematic review of mapping-based teaching strategies in pediatric nursing education: effects on learning outcomes among nurses and nursing students. [PDF]

BMC Med Educ
Sawalha MA, Alrabab'a MH, Elshatarat RA, Mayyas SM, Murad AA, Abdelkader R, Alnawafleh KA, Aboelmagd AN, Saleh ZT, Al-Sayaghi KM.   +9 more
europepmc   +1 more source

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

PEDIATRICS

Journal of Cancer Research and Therapeutics
openaire   +2 more sources

Pediatric Dacryocystorhinostomy

Indian Journal of Ophthalmology, 2017
openaire   +3 more sources

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source