Results 211 to 220 of about 1,419,974 (261)

A Pan‐Methylome Framework for Population‐Scale Bacterial Epigenomics

Advanced Science, EarlyView.
A scalable quantitative framework unlocks population‐level comparative epigenomics in bacteria. By transforming site‐level data into standardized traits, this approach reconstructs methylation‐informed phylogenies and defines the core epigenome.
Bin Ma, Huimin Gong, Ran Zhuo, Zaixiao Rao, Yanxi Wan, Mingyang Wang, Zahra Zeinalzadeh, Yuan Gao, Aohan Guan, Xinrun Li, Wanting Chen, Xiliang Wang, Yun Wan, Sihua Zhang, Yuncai Xiao, Qi Huang, Paul R. Langford, Xiangru Wang, Rui Zhou, Rui Luo, Hongbo Zhou, Chengliang Zhu, Hui Jin   +22 more
wiley   +1 more source

Transforming pediatric oncology in Ecuador through the Global Platform for Access to Childhood Cancer Medicines. [PDF]

Rev Panam Salud Publica
Lissette M, Vásquez L, Guerrero C, Villacrés N, Antiporta DA, Lavayen M, Meza K, Solís P, Santana D, Solís R, Del Carmen Trujillo M, Solórzano G, Sánchez L, Calle D, Bonilla D, Sanchez G, Espin L, Guerrero E, Cedeño R, Jimenez S, Morales A, Kasper T, Millan S, Alcocer P, Lim C, Maza M, Luciani S, Rodríguez-Galindo C, Quezada S.   +28 more
europepmc   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Extracorporeal carbon dioxide removal integrated into continuous renal replacement therapy in pediatric patients with ARDS: a retrospective single-center case series. [PDF]

BMC Pediatr
Kuntz M, Matheisl D, Schüle I, Klotz D, Fuchs H, Schneider H.   +5 more
europepmc   +1 more source

WDR72 Promotes Neuroblastoma Stemness and Progression by Sequestering TRIM31‐Mediated Degradation of CBX8

Advanced Science, EarlyView.
This study unveiled that METTL14 mediates m6A modification of WDR72 mRNA to stabilize and enhance WDR72 expression, which disrupts TRIM31‐mediated ubiquitination of CBX8 protein and retards its degradation, finally the elevated CBX8 contributes to tumor stemness.
Huijuan Zeng, Zijie Ye, Manna Zheng, Jing Pan, Tianbao Tan, Jiliang Yang, Jiahao Li, Zhang Zhao, Tianzhu Long, Liyu Zhang, Gautam Sethi, Tianyou Yang, Chao Hu, Yan Zou   +13 more
wiley   +1 more source

Health-Related Quality of Life in Children with X-Linked Hypophosphatemia Treated with Burosumab: Real-World Data from a German-Swiss Study. [PDF]

Calcif Tissue Int
Böckmann I, Klein M, Mutze H, Rehberg M, Spartà G, Evers K, Schlingmann KP, Kemper MJ, Richter-Unruh A, Schmidt D, Hiort O, Grohmann-Held K, Schröder C, Derichs U, Freiberg C, Weitz M, Dunstheimer D, Schmid E, John-Kroegel U, Metzing O, Heger S, Jorch N, Staude H, Patzer L, Wühl E, Partsch CJ, Hübner A, Marx M, Land C, Albers N, Banzer J, Baus I, Wilkening F, Möller K, Wagner V, Krauch G, Gessner M, Goischke A, Leifheit-Nestler M, Zivicnjak M, Schnabel D, Haffner D, German Society for Pediatric Nephrology (GPN) and the German Society for Pediatric and Adolescent Endocrinology and Diabetology (DGPAED).   +42 more
europepmc   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Pediatric intensive care follow-up in Germany is rarely established and highly heterogeneous: a nationwide survey of 20 PICUs. [PDF]

Mol Cell Pediatr
Goretzki SC, Biedermann R, Brenner S, Daniels A, Dohna-Schwake C, Fiedler K, Fortmann I, Fuchs H, Giese S, Heimann K, Härtel C, Hort S, Irlbeck S, Lampe S, Lieftüchter V, Masjosthusmann K, Merker M, Overberg D, Reiss I, Sentner CP, Soler Wenglein J, Heuvel IVD, Vierzig A, Warncke G, Westhoff JH, Mand N, Bruns N, Section of Pediatric Intensive Care, Emergency Medicine of the German Interdisciplinary Association of Intensive Care, Emergency Medicine (DIVI).   +29 more
europepmc   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source