Results 81 to 90 of about 683,407 (303)

The effect of remimazolam-based total intravenous anesthesia versus sevoflurane-based inhalation anesthesia on emergence delirium in children undergoing tonsillectomy and adenoidectomy: study protocol for a prospective randomized controlled trial

Frontiers in Pharmacology
Background: Remimazolam, a new ultrashort-acting benzodiazepine, is becoming increasingly applied in general anesthesia. This study is designed to investigate the effect of remimazolam-based total intravenous anesthesia and sevoflurane-based inhalation ...
Hong-Yu Ma, Hong-Yu Ma, Hong-Yu Ma, Yu-Hang Cai, Yu-Hang Cai, Yu-Hang Cai, John Wei Zhong, Jia Chen, Jia Chen, Jia Chen, Zhen Wang, Chao-Yi Lin, Chao-Yi Lin, Chao-Yi Lin, Qiao-Qiao Wang, Qiao-Qiao Wang, Qiao-Qiao Wang, Hua-Cheng Liu, Hua-Cheng Liu, Hua-Cheng Liu   +19 more
doaj   +1 more source

Pediatric Phantom Dosimetry Evaluation of the Extraoral Bitewing

, 2020
Purpose: This study’s purpose was to evaluate the effective dose (E) and equivalent dose (HT) of exposing a pediatric phantom to the extraoral bitewing programs of the Planmeca ProMax 2D S3 (ProMax) and Instrumentarium Orthopantomograph OP30 (OP30) and ...
Tang, Qing, Wiley, Dillon, Sanders, Brian J., Yepes, Juan F., Jones, James E., Johnson, K. Brandon   +5 more
core  

Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring

Advanced Science, EarlyView.
An engineered allosteric biosensor (UUU‐DZ‐tFNA) was developed, in which UDG specifically recognizes and activates a DNAzyme to achieve signal cycle amplification in a sequentially activatable mode. UUU‐DZ‐tFNA achieves in situ UDG detection across multiple biological levels and facilitates risk stratification and drug resistance monitoring of NB ...
Yaqing Lu, Yingyu Zhang, Xianwei Zhang, Mengxin Zhang, Fei Zhang, Jushan Sun, Yahui Yang, Kangbo Liu, Peng Wang, Shuying Luo, Wancun Zhang   +10 more
wiley   +1 more source

Comparison of 0.2% Ropivacaine and 0.25% Bupivacaine in Pediatric Caudal Block : Evaluation of Postoperative Pain and Plasma Concentration of Local Anesthetics [PDF]

, 2007
The purpose of this study is to assess the effects of pediatric caudal block using 0.2% ropivacaine or 0.25% bupivacaine on intraoperative and postoperative analgesia. We also examined plasma concentrations of the local anesthetics after caudal injection.
Nagai, Toshiaki, Hashizume, Yoshitaka, Fukagawa, Daigo, Yamaguchi, Shigeki, Hamaguchi, Shinsuke, Ikeda, Tomohito   +5 more
core  

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

Regional Anesthesia to Save the Day for Kids: A Narrative Review of Literature About the Blocks to Know for Common Pediatric Surgeries

Medicina
Postoperative pain management in pediatric patients remains a significant challenge despite improvements in perioperative care. Regional anesthesia techniques applied as part of multimodal analgesia strategies offer the potential to reduce opioid use ...
Hadi Ufuk Yörükoğlu, Can Aksu, Nur Nazire Yucal, Sevim Cesur, Alparslan Kuş   +4 more
doaj   +1 more source

General Anesthesia in Pediatrics

, 2021
General Anesthesia has been in use for decades and the field is growing very rapidly with many new agents continuously being developed. The human body’s metabolism and organ functions are constantly changing with age; thus, the drug pharmacokinetics and ...
Mansour, Abboud
core  

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Characterization of neonatal anesthesia in Colombia from a multidisciplinary perspective. Observational study

Colombian Journal of Anesthesiology
Introduction: The neonatal period, encompassing the first 28 days of life, is marked by low functional reserve and adaptation to extrauterine life. Neonates have higher postoperative morbidity and mortality compared to older pediatric patients.
Alexander Trujillo Mejía, Alejandro Jaramillo, Fernando Arango   +2 more
doaj   +1 more source

Immune Biomarkers of Islet Transplant Rejection Revealed by Synthetic Immunological Niche

Advanced Science, EarlyView.
A subcutaneous synthetic immunological niche (IN) enables serial, minimally invasive monitoring of immune responses after islet transplantation. Flow cytometry and transcriptomic profiling of the IN reveal immune‐cell programs associated with graft acceptance and distinct types of rejection.
Jyotirmoy Roy, Abdalmonam Jadou Nejma, Mohammad Tarique, Amod Talekar, Shengli Wu, Brianna Ha, Yifei Jiang, Esma S. Yolcu, Lonnie D. Shea   +8 more
wiley   +1 more source