Results 251 to 260 of about 607,508 (353)

Therapeutic Gene Editing: DNA Repair Pathways, Emerging Editors, and Clinical Progress

iNew Medicine, EarlyView.
ABSTRACT The field of gene editing has evolved rapidly over the past decade, progressing from programmable zinc‐finger nucleases (ZFNs) and transcription activator‐like effector nucleases (TALENs) to the widespread adoption of CRISPR‐Cas systems. First‐generation editors catalyzed genome engineering by introducing targeted double‐strand breaks (DSBs ...
Li‐Kuang Tsai, Youcai Xiong, Dongqi Liu, Dongshan Yang, Jifeng Zhang, Jie Xu, Renzhi Han, Y. Eugene Chen   +7 more
wiley   +1 more source

Acute Poisoning in Children Presenting to the Pediatric Emergency Department: An Epidemiologic Study and the Impact of the SARS-CoV-2 Pandemic. [PDF]

Medicina (Kaunas)
Di Sarno L, Pansini V, Caroselli A, Soave PM, Gatto A, Ferretti S, Capossela L, Chiaretti A.   +7 more
europepmc   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

A Game Changer for Acute Gastroenteritis in the Pediatric Emergency Department: Multiplex Stool PCR Test. [PDF]

J Clin Lab Anal
Barut D, Turan C, Boluk E, Aydemir S, Yurtseven A, Saz EU.   +5 more
europepmc   +1 more source

Time Out: A Scoping Review of Non‐Duration Based Social Media Use Measures and Adolescent Mental Health

Journal of Adolescence, EarlyView.
ABSTRACT Introduction Research to understand the role of social media use (SMU) in explaining deteriorating adolescent mental health has been limited by broad, nonspecific measures of social media use, specifically ‘time spent on social media’. These measures provide insufficient detail to capture specific risk and protective factors to users.
Amanda M. Sursely, Bengi Baran, Gerta Bardhoshi, Jonathan M. Platt   +3 more
wiley   +1 more source

Increasing a hospital-based violence intervention program's referrals for children and families in a pediatric emergency department. [PDF]

Inj Epidemiol
Khan NI, Chinta SS, Cheaton BM, Nimmer M, Levas MN.   +4 more
europepmc   +1 more source

Validation of Hexaplex Recombinase Polymerase Amplification Assay for the Detection of Carbapenemase Genes in Klebsiella pneumoniae Isolates From Pediatric Inpatients

Journal of Clinical Laboratory Analysis, EarlyView.
A novel hexaplex recombinase polymerase amplification (RPA) method was developed to rapidly and accurately detect five key carbapenemase genes and a Klebsiella pneumoniae‐specific target in a single reaction. This makes it an effective tool for CRKP detection in resource‐constrained environments.
Suthawan Mutitanon, Nuntaree Chaichanawongsaroj   +1 more
wiley   +1 more source

Lesson from a Single Pediatric Emergency Department: Potentially Applicable Radiation-Minimizing Practices for Non-Traumatic Abdominal Pain in Adolescents. [PDF]

Children (Basel)
Chun MK, Yoo R, Lim SY, Kim D, Han J, Choi SJ, Lee JY, Lee JS, Park JS.   +8 more
europepmc   +1 more source

Diagnostic Concordance of Two‐ and Three‐Gene SARS‐CoV‐2 Molecular Assays in Cameroon: Implications for Efficient Pandemic Response in Low‐ and Middle‐Income Countries

Journal of Clinical Laboratory Analysis, EarlyView.
This study assessed the interoperability of DaAn Gene, ThermoFisher, and GeneXpert assays used for COVID‐19 testing in Cameroon. GeneXpert showed higher diagnostic performance over ThermoFisher, with all assays having excellent agreement at high viral loads (CT < 20).
Aurelie Minelle Kengni Ngueko, Sandrine Claire Djupsa Ndjeyep, Ezechiel Ngoufack Jagni Semengue, Alex Durand Nka, Collins Ambe Chenwi, Aude Christelle Ka'e, Yagai Bouba, Jeremiah Efakika Gabisa, Evariste Molimbou, Naomi‐Karell Etame, Tatiana Anim‐Keng Tekoh, Rachel Audrey Nayang Mundo, Pamela Patricia Tueguem, Vincent Kamael Mekel, Hugues Mba, Désiré Takou, Grace Angong Beloumou, Michel Carlos Tommo Tchouaket, Larissa Gaelle Moko Fotso, Derrick Tambe Ayuk, Christian Ngongang Ouankou, Claudia Alteri, Luna Colagrossi, Yap Boum II, Halle Gregory Eddy Ekane, Francesca Ceccherini‐Silberstein, Vittorio Colizzi, Nicaise Ndembi, Alfred K. Njamnshi, Alexis Ndjolo, Carlo‐Federico Perno, Maria‐Mercedes Santoro, Joseph Fokam   +32 more
wiley   +1 more source

Firearm Screening and Gun Lock Distribution in an Urban, Academic Pediatric Emergency Department. [PDF]

Pediatr Emerg Care
Timm T, Mueller K, Lim M, An M, Jamro-Comer E, Ahmad FA, Clukies L.   +6 more
europepmc   +1 more source