Results 41 to 50 of about 7,386 (125)

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, EarlyView.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source

Epidemiology of progressive intellectual and neurological deterioration in UK children

Developmental Medicine &Child Neurology, Volume 68, Issue 3, Page 418-428, March 2026.
This study of PIND in UK children was carried out via the British Paediatric Surveillance Unit from 1997 to 2024. It identified six cases of vCJD. 2367 children had other diagnoses explain their deterioration. There were 259 other diseases in the diagnosed group.
Christopher M. Verity, Polly J. Maunder, Anne Marie Winstone, Suvankar Pal   +3 more
wiley   +1 more source

Changes in Italian Nurses' Genetic Knowledge and Perceptions Over a Decade

Nursing &Health Sciences, Volume 28, Issue 1, March 2026.
ABSTRACT Genetic knowledge is increasingly important in nursing, yet often seen as of limited relevance. This study examines Italian nurses' genetic knowledge and perceived relevance, comparing current findings with data from a 2011 survey. A cross‐sectional survey was carried out using a self‐administered questionnaire. A total of 504 nurses (95.1% of
Lea Godino, Camilla Elena Magi, Mattia Ricco, Daniela Turchetti   +3 more
wiley   +1 more source

Reduced intracranial volume in Fabry Disease: Evidence of abnormal neurodevelopment? [PDF]

, 2018
Introduction: Lysosomal storage disorders (LSD) are often characterized by abnormal brain development, reflected by a reduction of intracranial volume (ICV).
Brunetti, Arturo, Cocozza, Sirio, Morra, Vincenzo Brescia, Pisani, Antonio, Pontillo, Giuseppe, Quarantelli, Mario, Riccio, Eleonora, Russo, Camilla, Saccà, Francesco, Tedeschi, Enrico   +9 more
core   +2 more sources

APP‐mediated intracellular signaling rescues sleep impairment and blood–brain barrier leakage in Alzheimer's disease mouse model

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Amyloid beta peptide (Aβ) accumulation in the brain is an Alzheimer´s disease (AD) hallmark. Sleep disturbances hamper Aβ production and clearance, thereby exacerbating the Aβ burden. The mechanisms involved remain unclear. We reported that amyloid precursor protein (APP), the Aβ source, possesses intracellular signaling that ...
Clémentine Puech, Anjana Sadanand, Neil Coleman, Marilyn Ikhane, Mohammad Badran, Rong Wang, David Gozal, Angèle T. Parent   +7 more
wiley   +1 more source

Quasi-diffusion magnetic resonance imaging (QDI): A fast, high b-value diffusion imaging technique. [PDF]

, 2020
To enable application of non-Gaussian diffusion magnetic resonance imaging (dMRI) techniques in large-scale clinical trials and facilitate translation to clinical practice there is a requirement for fast, high contrast, techniques that are sensitive to ...
Barrick, TR, Hall, MG, Howe, FA, Ingo, C, Isaacs, JD, Jones, TL, Madigan, J, Magin, RL, Rich, P, Spilling, CA   +9 more
core   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Functional analysis and transcriptional output of the Göttingen minipig genome [PDF]

, 2015
In the past decade the Göttingen minipig has gained increasing recognition as animal model in pharmaceutical and safety research because it recapitulates many aspects of human physiology and metabolism.
Badi, Laura, Berrera, Marco, Bishop, Richard, Certa, Ulrich, Daff, Hamina, Daubenberger, Claudia, Ebeling, Martin, Heckel, Tobias, Khan, Azinwi Phina, Kiialainen, Anna, Kratochwil, Nicole A., Kuhn, Bernd, Küng, Erich, Lekolool, Isaac, Nowaczyk, Corinne, Okoth, Edward, Pelle, Roger, Ravon, Morgane, Ringshandl, Stephan, Schmitt, Georg, Schmucki, Roland, Steiner, Guido   +21 more
core   +9 more sources

E‐Textiles in Biomedicine: Real Time Sensing, Energy Storage, and Therapeutic Applications

Advanced Materials Interfaces, Volume 13, Issue 1, 7 January 2026.
E‐textiles merge electronics with fabrics to create intelligent, wearable systems for health, sports, and fashion. By embedding sensors, actuators, and conductive components, these textiles provide real‐time physiological monitoring. Complemented by flexible power sources including embedded batteries and energy‐harvesting technologies, e‐textiles ...
Shiva Sharma, Sudheesh K. Shukla, Atheesha Singh, Krishna K. Govender, Penny P. Govender   +4 more
wiley   +1 more source