Results 201 to 210 of about 154,348 (262)

Factors associated with first-attempt success of peripheral arterial catheterization in a pediatric intensive care unit: a prospective observational study. [PDF]

Front Pediatr
Li J, Zhou M, He Q, Fu K, Wang Q, Dong Q, Gu Y, Wang L.   +7 more
europepmc   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Therapeutic Plasma Exchange in Pediatric Intensive Care and Brief Overview of the Literature. [PDF]

Sisli Etfal Hastan Tip Bul
Ozel A, Barlas UK, Yuce S, Boyraz M, Erol M.   +4 more
europepmc   +1 more source

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

Creatinine, but not cystatin C, varies diurnally in critically ill children: a retrospective analysis from a tertiary pediatric intensive care unit. [PDF]

Eur J Pediatr
Frithiof R, Eriksson MB, Cedernaes J, Modiri AR, Smekal D, Larsson A.   +5 more
europepmc   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Overcoming barriers to pediatric intensive care in low-resource settings: an institutional experience from Northeast India. [PDF]

Health Policy Plan
Tsanglao WR, Kikon S, Aier T.
europepmc   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Understanding infant stress in neonatal and pediatric intensive care: a scoping review. [PDF]

Intensive Care Med Paediatr Neonatal
Riley C, Mastropietro C, Darcy-Mahoney A, Pintz C, Zhou QP, Hinds PS.   +5 more
europepmc   +1 more source

Multidrug-resistant organism carriage in children admitted to a pediatric intensive care unit of a Greek tertiary hospital: prevalence and risk factors. [PDF]

Antimicrob Resist Infect Control
Rozakea OP, Psallida P, Doudoulakakis A, Patsoura A, Soldatou A.   +4 more
europepmc   +1 more source