Results 221 to 230 of about 329,701 (306)

Factors associated with weaning success from prolonged mechanical ventilation in surviving Chinese pediatric intensive care units: a multicenter analysis. [PDF]

Front Pediatr
Li T, Zhang Z, Ren H, Liu C, Yang Z, Cheng Y, Xu W, Qu D, Gao H, Zhang F, Miao H, Ye F, Li M, Tao J, Zhang J, Huang L, Chen W.   +16 more
europepmc   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Distribution of pediatric intensive care beds in Brazil: Regional inequalities and implications for equity in the public health system. [PDF]

PLoS One
Soares LFR, Mendes Gomes MAS, Gomes Júnior SC.   +2 more
europepmc   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Overnight extubation and risk of extubation failure in patients in the pediatric intensive care unit: an exploratory review. [PDF]

Front Pediatr
Payán-Salcedo HA, Sandoval VO, Castro Ibarguen BD, Ramírez YL, Cortés González SL, Arzayus-Patiño L.   +5 more
europepmc   +1 more source

Digital diagnostics, biomarkers and therapeutics in an evolving healthcare system: From promise to practice

British Journal of Clinical Pharmacology, EarlyView.
Abstract Health care is shifting towards a digital‐guided system, integrating digital diagnostics, biomarkers and therapeutics in many care pathways. However, despite rapid technological advancement and preliminary adoption accelerated by the COVID‐19 pandemic, a significant implementation gap persists. This narrative review explores the causes of this
Mees H. P. Stoop, Gertjan J. A. Driessen, Adam F. Cohen, Matthijs D. Kruizinga   +3 more
wiley   +1 more source

Incorporating Lung-involved Malignancies into Pediatric Intensive Care Unit Risk Models. [PDF]

Indian J Crit Care Med
Li W, Xia B.
europepmc   +1 more source

Systematic review and scoring‐based selection of pharmacokinetic models for precision dosing of vancomycin in neonates and children

British Journal of Clinical Pharmacology, EarlyView.
This systematic review identified 112 population pharmacokinetic models of vancomycin in neonates and children. To support rational model selection for model‐informed precision, we developed and applied expert‐driven, transparent criteria that integrate both methodological rigour and clinical relevance.
Zoë Vander Elst, Pieter‐Jan Spiessens, Dorian Vanneste, Nada Dia, Matthias Gijsen, Isabel Spriet, Karel Allegaert, Erwin Dreesen, Anne Smits   +8 more
wiley   +1 more source

The effect of in-hospital follow-up on early post-transfer distress in families of patients in pediatric intensive care unit. [PDF]

Front Med (Lausanne)
Peng D, Peng J, Wu X, Liu Y, He Z, Hu M, Huang T, Chen Y, Yang Y, Liu M, Zhang X.   +10 more
europepmc   +1 more source