Results 101 to 110 of about 5,778,311 (262)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Sevoflurane improves respiratory mechanics and gas exchange in a case series of infants with severe bronchiolitis‐induced acute respiratory distress syndrome

Clinical Case Reports, 2018
Key Clinical Message This report describes the successful use of a new intervention to improve respiratory mechanics and gas exchange in a relatively homogeneous group of infants with severe bronchiolitis‐induced PARDS after failure of conventional ...
Mirco Nacoti, Jacopo Colombo, Oliviero Fochi, Daniele Bonacina, Francesco Fazzi, Giacomo Bellani, Ezio Bonanomi   +6 more
doaj   +1 more source

Prader-Willi Syndrome: an under-recognized cause of hypotonia?

Journal of Pediatric and Neonatal Individualized Medicine, 2017
The “floppy infant” is a well-recognized entity characterized by general­ized hypotonia presenting at birth or in early life. Hypotonia represents a diagnostic challenge because it may be the presentation sign of numerous diseases, as central or ...
Marlene Rodrigues, Miguel Costa, Joana Teixeira, Carla Sá, Liliana Pinheiro, Eduarda Abreu, Albina Silva, Nicole Silva, Matos Marques, Miguel Rocha, Almerinda Pereira   +10 more
doaj   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Neuroleptic Malignant Syndrome Requiring Neurological Intensive Care Unit Follow-up: Review with Nine Cases

, 2014
Neuroleptic malignant syndrome (NMS) is a rare but life-threatening clinical manifestation induced by neuroleptic medication. Although NMS is regarded as a psychiatric diagnosis, its treatment requires a systematic approach and thus intensive care follow-
Yeşim Beckmann, Galip Akhan, Yaprak Seçil, Nazlı Gamze Bülbül, Tülay Kurt İncesu   +4 more
core   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Hemodynamic effects of intravenous paracetamol in critically ill children with septic shock on inotropic support

Journal of Intensive Care, 2020
Background Treatment with intravenous paracetamol may impair hemodynamics in critically ill adults. Few data are available in children. The aim of this study was to investigate the frequency, extent, and risk factors of hypotension following intravenous ...
Elhanan Nahum, Avichai Weissbach, Eytan Kaplan, Gili Kadmon   +3 more
doaj   +1 more source

Differences in the perceptions of parents and healthcare professionals on pediatric intensive care practices

, 2011
Objective: To explore similarities and differences in perceptions on pediatric intensive care practices between parents and staff by using data from two studies.
Hazelzet, J.A., Jan A. Hazelzet, van Goudoever, Johannes B., Latour, J.M., van Heerde, M., Van Dam, N., de Neef, M, Albers, Marcel J. I. J., de Neef, Majorie, Jos M. Latour, Albers, MJIJ, Duivenvoorden, Hugo, Van Vught, E., Nicolette A. M. van Dam, Verlaat, CWM, Duivenvoorden, Hugo J., de Neef, M., Dullaart, Eugenie, Verlaat, Carin W. M., van Goudoever, J.B., Hazelzet, Jan A., van Vught, EM, Duivenvoorden, H., Dullaart, E., Van Goudoever, J., de Neef, Marjorie, Albers, M.J.I.J., Marc van Heerde, van Vught, E.M., Verlaat, C., Latour, Jos M., Marjorie de Neef, Carin W. M. Verlaat, Johannes B. van Goudoever, Verlaat, C.W.M., van Dam, NAM, Hugo J. Duivenvoorden, Marcel J. I. J. Albers, Elise M. van Vught, Dullaart, E, Hazelzet, Jan, Eugenie Dullaart, van Dam, N.A.M., van Vught, Elise M., Latour, Jos, van Heerde, Marc, Albers, M., van Heerde, M, Hazelzet, J., van Dam, Nicolette A. M., Duivenvoorden, H.J., Goudoever, Johan   +51 more
core   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

Simple prognostic markers to predict mortality in intensive care unit: Red cell distribution width

, 2021
Background: We tried to examine association between the prognostic intensive care unit (ICU) scores and red cell distribution width (RDW) for prediction of mortality in a cohort of ICU patients at a single centre in Turkey.Methods: This is a ...
Erdogan, Ahmet, Uckan, Enes Malik, Erdem, Deniz, Tez, Mesut   +3 more
core   +1 more source