Results 131 to 140 of about 118,364 (315)

Associação entre terapia nutricional, estado nutricional e tempo de ventilação mecânica em pacientes pediátricos graves [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Nutrição, Florianópolis, 2014.Introdução: A desnutrição em pacientes pediátricos graves está associada com desfechos clínicos ...
Grippa, Rafaela Bouvie
core  

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

Relationship between Maternal Stress and Neurobehavioral Indicators of Preterm Infants in the Neonatal Intensive Care Unit

Background: Preterm birth and prolonged neonatal hospitalization are potential sources of stress for mothers of preterm and low birth weight infants. Aim: To evaluate maternal stress and its association with neurobehavioral indicators of preterm infants ...
Patricia Gonçalves Evangelista Marçal, Cibelle Kayenne Martins Roberto Formiga, Waldemar Naves do Amaral, Bruna Abreu Ramos, Nayara Rodrigues Gomes de Oliveira, Tárik Kassem Saidah, Rui Gilberto Ferreira   +6 more
core   +1 more source

Evaluation of Central Venous Catheterization Complications and Related Risk Factors in a Pediatric Intensive Care Unit

, 2016
Objective: In this study, we aimed to evaluate central venous catheter insertion related complications and related risk factors in a pediatric intensive care ...
Coskun, Ramazan, Ozcan, Alper, Kose, Secil, Torun, Yasemin Altuner, Ergul, Ayse Betul, Aslaner, Haci Ahmet, Aslaner, Humeyra   +6 more
core   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Construção de um guia de cuidados de enfermagem para a prevenção de incidentes na via intravenosa: implicações para a segurança do paciente pediátrico [PDF]

, 2015
Dissertação (mestrado profissional) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Gestão do Cuidado em Enfermagem, Florianópolis, 2015.A segurança do paciente nos serviços de saúde é um tema que vem ...
Soncini, Marília de Farias
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Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

British Journal of Clinical Pharmacology, EarlyView.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga, Stefano Agliardi, Riccardo Giossi, Alice Schianchi, Alessandra Romandini, Thomas Virdis, Silvia Nerini Molteni, Maria Luisa De Angelis, Stefania Paccagnini, Cecilia Gechtman, Alice Proto, Marco Fossati, Silvia Oliveri, Giulia Angela Pattarino, Elena Altieri, Agnese Graziosi, Arianna Pani, Romano Danesi, Stefano Martinelli, Costantino De Giacomo, Francesco Scaglione   +20 more
wiley   +1 more source

Pediatric Diabetic Ketoacidosis: A Retrospective Study on Triggering Factors and Complications in a Turkish Intensive Care Unit [PDF]

Aim: Diabetic ketoacidosis (DKA) is a critical, potentially life-threatening complication of diabetes mellitus (DM) in children, characterized by hyperglycemia, acidosis, and ketonemia/ketonuria.
Ayşe Aşık, Meltem Ermaydan, Muhterem Duyu, Ayşe Şevval Demir   +3 more
core   +1 more source

Contraindicated drug–drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval, Sylvain Goutelle, Inesse Boussaha, Xavier Dode, Yanis Mimouni, Kim An Nguyen, Behrouz Kassai   +6 more
wiley   +1 more source

Case‐malformed signal detection and prioritisation using EUROmediCAT data for pharmacovigilance in pregnancy

British Journal of Clinical Pharmacology, EarlyView.
Aim Many women take medications during pregnancy. However, the risk to the fetus from most medications is uncertain. Congenital anomalies are one of the leading causes of infant death and contribute to long‐term disability. Signal detection methods can be used to systematically identify possible medication–anomaly associations that require further ...
Hannah Johnson, Helen Dolk, Maria Loane, Christine Damase‐Michel, Joanne Given, Hedvig Nordeng, Jorieke E. H. Bergman, Iain Carey, Elly Den Hond, Ester Garne, Florence Rouget, Lea Bruneau, Isabelle Monier, Anke Rissmann, Mary O'Mahony, Miriam Gatt, Renée Lutke, Joanna Sichitiu, Elisa Ballardini, Alessio Coi, Clara Cavero Carbonell, David Tucker, Joan Morris   +22 more
wiley   +1 more source