Results 91 to 100 of about 1,073,095 (299)

Optimized Cas9‐Enriched Nanopore Sequencing and Analysis Workflow for Clinical Diagnosis of Repeat Expansion Disorders

Advanced Science, EarlyView.
An optimized Cas9‐enriched nanopore sequencing workflow, combined with STRiker, enables simultaneous analysis of disease‐associated STR loci from patient blood. The nCATS–STRiker workflow detects repeat expansions, de novo repeat motifs, interruption patterns, and methylation in a single assay, improving the genetic diagnosis of previously undiagnosed ...
Seungbok Lee, Chanju Jung, Minjeong Kim, Narae Kim, Gue‐Ho Hwang, Soon‐Tae Lee, Kon Chu, Sang Kun Lee, Han‐Joon Kim, Jong‐Hee Chae, Sangsu Bae, Jangsup Moon   +11 more
wiley   +1 more source

Social Responsibility and Commitment to Children; Pediatric Nurses’ Experiences With Redeployment During the First Wave of COVID-19: A Qualitative Study

Inquiry: The Journal of Health Care Organization, Provision, and Financing
COVID-19 represented a challenge for health care worldwide and led to new tasks and a rethinking of resource use. It was necessary to establish capacity within hospitals and to reassign critical resources between hospitals.
Nina Margrethe Kynø PhD, Anette Winger PhD, Edel Jannecke Svendsen PhD, Tove Elisabeth Augustin Børsting Master   +3 more
doaj   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

Fatigue and Its Related Factors in Pediatric and Adult Oncology Nurses

نشریه پرستاری ایران, 2011
Background & Aim: Pediatric and adult oncology wards have special characteristics which may lead to different levels of fatigue in nurses. The aim of this study was to compare fatigue and its related factors in pediatric and adult oncology nurses ...
Rassouli M, Zandiye S, Noorian M, Zayeri F   +3 more
doaj  

Moral sensitivity of pediatric nurses

, 2017
Moral sensitivity is the first component of ethical decision-making. This decriptive-type study was conducted to determine moral sensitivity of pediatric nurses. The study sample consisted of 97 pediatric nurses.
Çetinkaya, Bengü, Başkale, Hatice
core  

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Perceptions of pediatric nurses by mothers of children with hospitalization experience: A qualitative study.

Introduction: A child's illness or hospitalization is a complex process experienced by the child, parents, and family members. Methods: The purpose of this study is to determine the perceptions of pediatric nurses by mothers of hospitalized children.
Ozbey, H., Bayat, M., Efe, Y.S., Caner, N., Platin, N., Erdemir, Firdevs, Dudukcu, F.T., Platin, Nurgun, Sezer Efe, Yağmur, Caner, Nuray, Erdemir, F., Dudukcu, Figen Turk, Bayat, Meral, TÜRK DÜDÜKÇÜ, Figen, Özbey, Harun   +14 more
core   +1 more source

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

Development and psychometric testing of the Pediatric Atraumatic Care Attitude Scale (PACAS) in pediatric nurses

Objective: The study aimed to develop and validate the Pediatric Atraumatic Care Attitude Scale (PACAS) for pediatric nurses, measuring attitudes toward atraumatic care practices.
Elmaoğlu, Erhan, Bektaş, Murat, Coşkun, Adnan Batuhan   +2 more
core   +2 more sources

A Living Multi‐Omics PDX Biobank of High‐Risk Sarcomas Reveals ecDNA‐Driven Oncogene Amplification in Osteosarcoma and Enables Preclinical Precision Oncology

Advanced Science, EarlyView.
A living multi‐omics sarcoma PDX biobank is enriched for high‐risk disease and preserves key patient tumor features at histopathological and molecular levels. Integrated profiling reveals ecDNA‐driven oncogene amplification in osteosarcoma and preferential retention of ecDNA during PDX evolution.
Weisong Zhao, Zhiwei Cheng, Kai Tian, Mengxiong Sun, Zhuoying Wang, Ming Jiao, Jens Luebeck, Kaiyuan Zhu, Xiao Zhang, Dongqing Zuo, Hongsheng Wang, Chongren Wang, Jiakang Shen, Xiaojun Ma, Gangyang Wang, Zongyi Wang, Jing Han, Kaiyuan Liu, Haoran Mu, Weiqi Ma, Yongyong Ren, Shibing Guo, Huangxin Tu, Lingfeng Yu, Yining Tao, Yu Lv, Hui Lu, Owen S. Chapman, Rishaan Kenkre, Lukas Chavez, Zhengdong Cai, Yuqin Yang, Wei Sun, Yafei Jiang, Yingqi Hua   +34 more
wiley   +1 more source