Results 111 to 120 of about 205,410 (305)

Long‐term impact of Elexacaftor/Tezacaftor/ivacaftor on pulmonary, nutritional and metabolic outcomes in homozygous F508del cystic fibrosis patients: A real‐world cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aim Elexacaftor/tezacaftor/ivacaftor (ETI) has markedly improved cystic fibrosis (CF) outcomes. However, its long‐term impact on nutrition, metabolism and liver health remains underexplored. We assessed 30‐month changes in pulmonary, nutritional, metabolic and inflammatory markers in people with CF (PwCF) homozygous for F508del.
Nicola Perrotta, Luigi Angelo Fiorito, Roberta Vescovo, Anna Virgilio, Giulia Amato, Giuseppe Cimino   +5 more
wiley   +1 more source

Comparative efficacy of GLP‐1 RA, tirzepatide and SGLT‐2 inhibitors in metabolic liver disease: A network meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aim Metabolic liver disease, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis, is a major cause of chronic liver dysfunction worldwide, creating an urgent need for effective treatments. This systematic literature review (SLR) and network meta‐analysis (NMA) systematically reviews and compares the efficacy and safety ...
Andrej Belančić, Christina Antza, Anastasios Poutachidis, Smaro Palaska, Elvira Meni Maria Gkrinia, Andrea Katrin Faour, Yusuf Ziya Sener, Seher Sener, Rehena Sultana   +8 more
wiley   +1 more source

Clinical effectiveness and predictors of response to topiramate plus lifestyle modification in youth with obesity seen in a weight management clinical setting

Frontiers in Endocrinology
IntroductionObesity affects approximately 20% of U.S. youth. Anti-obesity medications (AOMs) are promising lifestyle modification adjuncts for obesity treatment, and topiramate is commonly prescribed in pediatric weight management clinics.
Eric M. Bomberg, Eric M. Bomberg, Justin Clark, Kyle D. Rudser, Kyle D. Rudser, Amy C. Gross, Aaron S. Kelly, Claudia K. Fox   +7 more
doaj   +1 more source

Developmental Origins of Pediatric Obesity

International Journal of Pediatrics, 2012
Obesity is a global pandemic, with rates increasing in both the developed and developing world. Childhood obesity is a significant concern as it has negative consequences for other childhood morbidities and is often associated with adult obesity, diabetes, and cardiovascular disease.
Gahagan, Sheila, Uauy, Ricardo, Roseboom, Tessa J.   +2 more
openaire   +4 more sources

Associations between sleep duration, sedentary time, physical activity, and health indicators among Canadian children and youth using compositional analyses [PDF]

, 2016
The purpose of this study was to examine the relationships between movement behaviours (sleep duration, sedentary time, physical activity) and health indicators in a representative sample of children and youth using compositional analyses.
Carson, Valerie, Chaput, Jean-Philippe, Chastin, Sebastien F.M., Tremblay, Mark S.   +3 more
core   +1 more source

Systematic review and scoring‐based selection of pharmacokinetic models for precision dosing of vancomycin in neonates and children

British Journal of Clinical Pharmacology, EarlyView.
This systematic review identified 112 population pharmacokinetic models of vancomycin in neonates and children. To support rational model selection for model‐informed precision, we developed and applied expert‐driven, transparent criteria that integrate both methodological rigour and clinical relevance.
Zoë Vander Elst, Pieter‐Jan Spiessens, Dorian Vanneste, Nada Dia, Matthias Gijsen, Isabel Spriet, Karel Allegaert, Erwin Dreesen, Anne Smits   +8 more
wiley   +1 more source

Self-esteem and mood in obese children and their mothers: A pilot study [PDF]

, 2017
Objective: A test-retest pilot study was conducted to examine the relationship between overweight/obesity, self-esteem and mood in a group of school-age children, and the degree to which they changed after a tailored psycho-educational intervention ...
Cassutti, Valentina, Gatta, Michela, Miscioscia, Marina, Sale, Eleonora   +3 more
core  

Intravascular Lithotripsy Is Associated With Superior Clinical Outcomes Compared to Atherectomy: A Large‐Scale, Propensity‐Matched Analysis

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Coronary artery disease (CAD) with severe calcification remains a growing challenge in percutaneous coronary intervention (PCI). Atherectomy (ATH) has long been used for plaque modification, whereas intravascular lithotripsy (IVL) has emerged as a promising alternative. Large‐scale comparative data on long‐term outcomes are limited.
Charles D. Miks, Grant K. Ozaki, Chirayu R. Shukla, Vikram Sharma   +3 more
wiley   +1 more source

Attitudes and behaviors of pediatric surgical nurses toward pediatric patients with obesity in China

Frontiers in Public Health
BackgroundChildhood obesity is a growing global public health issue, with increasing prevalence worldwide, including in China. The rise in obesity-related pediatric conditions requiring surgical intervention underscores the need to address this challenge
Lijun Chang, Yanhua Gao, Yakun Liu
doaj   +1 more source

Does Weight Status Impact Metabolic Health in Adolescents When Controlling for Physical Fitness? [PDF]

, 2019
Purpose: To determines whether adolescents who are fit with overweight/obesity are similar in their metabolic profile to adolescents who are fit and normal weight. Methods: Adolescents participated in 3 sessions: (1) resting vitals and anthropometrics;
Bement, Marie K. Hoeger, Harkins, April L., Skelton, Joseph, Stolzman, Stacy   +3 more
core   +1 more source