Results 31 to 40 of about 97,890 (300)

Need for Representation of Pediatric Patients with Obesity in Clinical Trials

, 2023
Clinical trials are an integral aspect of drug development. Tremendous progress has been made in ensuring drug products are effective and safe for use in the intended pediatric population, but there remains a paucity of information to guide drug dosages ...
Jayabharathi Vaidyanathan, Rajanikanth Madabushi, Gilbert J. Burckart, Anuradha Ramamoorthy, Elimika Pfuma Fletcher, Sherbet Samuels   +5 more
core   +1 more source

The Edmonton Obesity Staging System for Pediatrics (EOSS-P) in Mexican Children and Adolescents Living with Obesity: Beyond BMI Obesity Classes

Children
Background/Objectives: The Edmonton Obesity Staging System (EOSS) was developed to stage the obesity in adult populations. Subsequently, this staging system was designed for pediatric populations (EOSS-P).
Isabel Omaña-Guzmán, Roberto Carlos Rodríguez Quintero, Arturo Ruíz-Arroyo, Edith Prado Díaz, Juan Carlos López-Alvarenga, Ana María Hernández López, Zendy Fuentes Corona, Karina Aguilar Cuarto, Karen Pedraza Escudero, Alejandra Ruíz Barranco, Erendira Villanueva-Ortega, Nayely Garibay-Nieto   +11 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Ketoacidosis at childhood type 1 diabetes onset negatively affects residual beta-cell functions during the first year after diagnosis

Scientific Reports
This study investigates whether pediatric patients presenting with diabetic ketoacidosis (DKA) at the time of type 1 diabetes (T1D) diagnosis experience increased insulin requirements, reduced rates of partial remission, and diminished C-peptide ...
Elżbieta Niechciał, Paulina Wais, Andrzej Kędzia   +2 more
doaj   +1 more source

The Effects of Maternal Endocrinopathies and Exposure to Endocrine Disruptors During Pregnancy on the Fetus and Newborn

Biomedicines
Maternal health has a profound impact on fetal development, influencing the risk of pediatric endocrine disorders both directly and indirectly through various biological and environmental mechanisms.
Ruth Fox, Su’ad Akinboro, Andrzej Kędzia, Elżbieta Niechciał   +3 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Nutritional Counseling in Children with Growth Hormone Deficiency Treated with Recombinant Human Growth Hormone: Analysis of Growth Response Parameters

Biomedicines
Background and Objectives: Growth failure is the main symptom of growth hormone deficiency (GHD) in children. The standard treatment for GHD is the administration of recombinant human growth hormone (rhGH).
Joanna Budzulak, Katarzyna Anna Majewska, Andrzej Kędzia   +2 more
doaj   +1 more source

Associations between paediatric fatigue and eating behaviours

Obesity Science & Practice, 2020
Summary Background In adults, poor sleep quality is associated with increased obesogenic eating behaviours; less is known about this relationship in youth.
Megan M. Oberle, Elise F. Northrop, Carolyn T. Bramante, Kyle D. Rudser, Amy C. Gross, Aaron S. Kelly   +5 more
doaj   +1 more source

Developmental Origins of Pediatric Obesity

International Journal of Pediatrics, 2012
Obesity is a global pandemic, with rates increasing in both the developed and developing world. Childhood obesity is a significant concern as it has negative consequences for other childhood morbidities and is often associated with adult obesity, diabetes, and cardiovascular disease.
Gahagan, Sheila, Uauy, Ricardo, Roseboom, Tessa J.   +2 more
openaire   +4 more sources