Results 171 to 180 of about 212,517 (305)

Single-Cell Transcriptomics Reveals Biomarkers for NK Cell Dysfunction in Endometriosis-Associated Immune Dysregulation

Mediators of Inflammation
Wangshu Li, Kexin Zhu, Bowen Xu, Juan Nie, Fang Wang, Aziz ur Rehman Aziz, Xiaohui Yu, Daqing Wang, Chunfang Ha   +8 more
doaj   +1 more source

Machine learning-predicted chromatin organization landscape across pediatric tumors. [PDF]

Sci Rep
Gjoni K, Zhang S, Yan RE, Zhang B, Miller D, Greenfield JP, Resnick A, Dahmane N, Pollard KS.   +8 more
europepmc   +1 more source

The Relevance of Preoperative Identification of the Adamkiewicz Artery in Posterior Mediastinal Pediatric Tumors. [PDF]

Ann Surg Oncol, 2022
Schmidt A, Hempel JM, Ellerkamp V, Warmann SW, Ernemann U, Fuchs J.   +5 more
europepmc   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

"Hadrontherapy for Life" Symposium, Caen, March 10/11, 2025-Strategy for the Future-Pediatric Tumors. [PDF]

Int J Part Ther
Habrand JL, Harrabi SB, Yamada S, Wang Z, Haghdoost S, Light E, Ohno T, Doyen J, Dendale R, Balosso J, Larnaudie A, Vela A, Pompos A, Hoppe B, Mahajan A, Thariat J.   +15 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Comprehensive analysis of mutational processes across 20 000 adult and pediatric tumors. [PDF]

Nucleic Acids Res
Villa M, Malighetti F, De Sano L, Villa AM, Cordani N, Aroldi A, Antoniotti M, Caravagna G, Graudenzi A, Piazza R, Mologni L, Ramazzotti D.   +11 more
europepmc   +1 more source

Expression of BARD1 β Isoform in Selected Pediatric Tumors. [PDF]

Genes (Basel), 2021
Jasiak A, Krawczyńska N, Iliszko M, Czarnota K, Buczkowski K, Stefanowicz J, Adamkiewicz-Drożyńska E, Cichosz G, Iżycka-Świeszewska E.   +8 more
europepmc   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Association of phosphorylation status of ERK and genetic MAPK alterations in pediatric tumors. [PDF]

Sci Rep
Selt F, Sigaud R, Korshunov A, Capper D, Reuss D, von Deimling A, Pajtler KW, van Tilburg CM, Nesper-Brock M, Jones DTW, Pfister SM, Sahm F, Witt O, Milde T, Ecker J.   +14 more
europepmc   +1 more source