Results 61 to 70 of about 212,517 (305)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Causes and risk factors for same-day discharge failure after total hip and knee arthroplasty: a meta-analysis

open access: yesScientific Reports
In recent decades, the trend toward early same-day discharge (SDD) after surgery has dramatically increased. Efforts to develop adequate risk stratification tools to guide decision-making regarding SDD versus prolonged hospitalization after total hip ...
José María Lamo-Espinosa   +4 more
doaj   +1 more source

Visual Outcome for Children with Optic Pathway Gliomas Treated with Systemic Chemotherapy

open access: yesClinical Ophthalmology, 2022
Mona Mohammad,1,* Hamzeh Mohammad Alrawashdeh,2,* Mustafa Mehyar,1 Nisreen Amayiri,3 Dima Abu Laban,4 Ibrahim Alnawaiseh,1 Yacoub Yousef1 1Department of Surgery, Division of Ophthalmology, King Hussein Cancer Center (KHCC), Amman, Jordan ...
Mohammad M   +6 more
doaj  

Medulloblastoma has a global impact on health related quality of life: Findings from an international cohort [PDF]

open access: yes, 2020
BACKGROUND: Understanding the global impact of medulloblastoma on health related quality of life (HRQL) is critical to characterizing the broad impact of this disease and realizing the benefits of modern treatments.
de Medeiros, Cynthia B   +2 more
core   +1 more source

DAX-1 Expression in Pediatric Rhabdomyosarcomas: Another Immunohistochemical Marker Useful in the Diagnosis of Translocation Positive Alveolar Rhabdomyosarcoma [PDF]

open access: yes, 2015
OBJECTIVES: The aim of this study was to investigate the expression of DAX-1 in a series of pediatric rhabdomyosarcomas (RMS) with known translocation and compare it to Ap2\u3b2, known to be selectively expressed in ARMS. DESIGN: We revised a series of
Alaggio, Rita   +10 more
core   +5 more sources

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait   +23 more
wiley   +1 more source

Genetic Predisposition to Solid Pediatric Cancers

open access: yesFrontiers in Oncology, 2020
Progresses over the past years have extensively improved our capacity to use genome-scale analyses—including high-density genotyping and exome and genome sequencing—to identify the genetic basis of pediatric tumors.
Mario Capasso   +10 more
doaj   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson   +3 more
wiley   +1 more source

Acute Lobar Nephronia in an infant presented as a renal tumor

open access: yesUrology Case Reports, 2021
A case report of a 02-month-old infant referred to us with incidental bilateral renal masses on ultrasound, which was reported as nephroblastoma/Wilms tumor on CT scan, no signs, and symptoms of infection.
Yasir Masood   +4 more
doaj   +1 more source

Thymoma with Myasthenia Gravis in Adolescent [PDF]

open access: yes, 2011
Thymomas are exceedingly rare in the first 20 years of life, Thymic lesions comprise approximately 2–3% of all pediatric mediastinal tumors and include thymic cysts, hyperplasia, carcinoma, and thymomas.
Balaiah, K   +3 more
core   +1 more source

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