Results 21 to 30 of about 24,934 (216)

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Eco‐Geography Reverses Dominant AMR Reservoirs in Klebsiella pneumoniae: Integron‐Rich Mobilomes and Cross‐Niche Connectivity

Advanced Science, EarlyView.
Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin, Biao Tang, Hao Xu, Jiajie Qian, Feifan Shi, Junhui Zhao, Xiaorui Mao, Xiaohe Hu, Ruishan Liu, Wenhong Liu, Xiawei Jiang, Beiwen Zheng, Guoping Zhao   +12 more
wiley   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

Geographical Pattern of Testicular Cancer Points to Maternal Exposures Behind Increasing Incidence

International Journal of Cancer, EarlyView.
ABSTRACT Evidence suggests that testicular cancer (TC) originates from germ cell neoplasia in situ arising during fetal development, implying that prenatal environmental exposures may influence disease risk. We investigated whether maternal place of residence during pregnancy is associated with regional variation in TC incidence.
Antti Kaipia, Karri Seppä, Elli Hirvonen, Eetu Mäkinen, Nea Malila, Janne Pitkäniemi, Jorma Toppari, Peter Boström, Heikki Seikkula   +8 more
wiley   +1 more source

Risk factors for not proceeding to reconstructive surgery after female genital mutilation: A cohort study of 220 women in a specialized referral center

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective This study identifies factors associated with not proceeding to clitoral reconstructive surgery among women with female genital mutilation (FGM) enrolled in a specialized surgical pathway. Methods A retrospective cohort study was conducted at a multidisciplinary referral center in Montreuil, France, between January 2021 and December ...
Félicia Joinau‐Zoulovits, Maëlle Silvestre De Sacy, Bruno Renevier, Sarah Abramowicz   +3 more
wiley   +1 more source

Examining the diagnostic process for ovarian cancer in Nova Scotia: A linked administrative data study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Ovarian cancer is the deadliest gynecological cancer in the developed world. The absence of screening for early detection of ovarian cancer and the non‐specific symptoms associated with the disease mean that timely diagnosis is difficult.
Chiara Gottheil, Christy Woolcott, Emily Gard Marshall, Katharina Kieser, Robin Urquhart   +4 more
wiley   +1 more source

Ragomics‐Meta: An open‐source, scalable, reproducible, and extensible multi‐omics analysis workflow

iMetaOmics, EarlyView.
Ragomics‐Meta is an open‐source, scalable, and reproducible multi‐omics workflow for metabolism‐centered analysis (https://www.raganetwork.com/). It integrates scRNA/snRNA‐seq, spatial transcriptomics, scATAC‐seq, and metabolomics modules to support quality control, dimensionality reduction, clustering, differential expression and accessibility ...
Zeping Gui, Huidong Su, Yuhao Chen, Jixing Yuan, Yexiu Gao, Ze Yu, Jing Zhang, Qingyi Zhu, Min Gu, Mulong Du, Zijie Wang, Ming Chen   +11 more
wiley   +1 more source

Klippel‐Trénaunay‐Weber Syndrome: Prenatal Diagnosis and Review of the Literature

Journal of Clinical Ultrasound, Volume 53, Issue 3, Page 535-546, March/April 2025.
This meta‐analysis demonstrates the high diagnostic accuracy of SZ‐CEUS for differentiating between malignant and benign focal liver lesions, as well as for HCC from non‐HCC lesions. The study shows better performance for smaller lesions and those with a higher proportion of malignancy.
Giuliana Orlandi, Laura Sarno, Antonio Angelino, Mariarosaria Motta, Raffaella Di Girolamo, Luigi Carbone, Marika Rovetto, Laura Letizia Mazzarelli, Gabriella Sglavo, Francesco D' Antonio, Ilenia Mappa, Daniele Di Mascio, Giuseppe Rizzo, Giuseppe Maria Maruotti   +13 more
wiley   +1 more source

Abdominal POCUS Education for Clinicians: A Systematic Review of Teaching Methods for Point‐of‐Care Abdominal Ultrasonography

Journal of Clinical Ultrasound, Volume 53, Issue 3, Page 547-561, March/April 2025.
For patients to benefit from abdominal point‐of‐care ultrasound, the ultrasound examinator must be sufficiently trained. In this systematic review, we identified advantages and disadvantages of different training methods and approaches. We conclude that thoughtful integration of the various educational methods is crucial for stakeholders and educators.
Birkir Örn Sveinsson, Olof Kristin Thorsteinsdottir, Alexander G. P. Browne, Benjamin S. B. Rasmussen, Anders Bo Nielsen, Pia Iben Pietersen   +5 more
wiley   +1 more source