Results 161 to 170 of about 87,547 (219)

Spinocerebellar ataxia type 2 with prominent manifestation of dystonia: one case report

Chinese Journal of Contemporary Neurology and Neurosurgery
ZHAO Ya-nan, LI Meng, FANG Yan-bo, DENG Wen-jing   +3 more
doaj   +1 more source

Analysis of Ancestral Inbreeding Across Main Founders and Ancestors in the Polish Simmental Cattle Population. [PDF]

Animals (Basel)
Kania-Gierdziewicz J, Otwinowska-Mindur A, Jarnecka O, Jagusiak W.   +3 more
europepmc   +1 more source

RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops

Advanced Science, EarlyView.
This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang, Yupo Wu, Jiachang Hou, Lixia Gao, Longqi Pan, Cuicui Shen, Chuanji Zhao, Feng Gao, Yi Zhang, Li Ren, Xiaoping Fang, Xiaoling Dun, Shengyi Liu, Lijiang Liu   +13 more
wiley   +1 more source

Case Report: Suspected hereditary spontaneous hydrocephalus in a Beagle pedigree. [PDF]

Front Vet Sci
Fu JW, Liu JY, Jin DJ, Huang JJ, Yang S, Deng JK, Gao Y, Han J, Liu Y, Xing Y, Liu YH, Zhang YP.   +11 more
europepmc   +1 more source

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

Advanced Science, EarlyView.
This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang, Jiani Deng, Man Yee Cheung, Tingting Fu, Xufeng Qi, Dongqing Cai, Jianmin Sun, Gang Lu, Peng Shi, Wai‐Yee Chan, Xu Li, Hui Zhao   +11 more
wiley   +1 more source

Fault-tolerant pedigree reconstruction from pairwise kinship relations. [PDF]

Bioinformatics
Huang EC, Li KA, Narasimhan VM.
europepmc   +1 more source

Single‐Cell Dissection of Microglial Dysfunction in Diabetes‐Associated Neurodegenerative Vulnerability

Advanced Science, EarlyView.
Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang, Tsz Kwan Yau, Joyce Tse, Tsz Ho Li, Dongjie Hu, Yong Juan Zhao, Ting‐Fung Chan   +6 more
wiley   +1 more source

Molecular and clinical characterization of a pedigree with factor XI deficiency, including a novel missense variant (p.Cys200Phe): a case report. [PDF]

J Med Case Rep
Cai R, Li Y, Liu P, Tan Y, Li F, Wang W, Feng Q.   +6 more
europepmc   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Family Tree Mapping of Genetic and Phenotypic Codes of Hereditary Angioedema. [PDF]

Medicina (Kaunas)
Baş İ, Gökmen E, Dizdar Canbaz T, Ay E, Kural RF, Aslan E, Ateş Ü, Kırdök K, Kilavuz A, Kaçmaz ME, Aykut A, Ayaz E, Özyaman F, Gülen F, Duman Şenol H.   +14 more
europepmc   +1 more source