Mechanobiological Dynamics‐Inspired Mechanomodulatory Biomaterials
Recent advances in biomaterial‐mediated mechanomodulation of stem cell fate, encompassing 2, 3, and 4D systems and their synergy with artificial intelligence is overviewed. By integrating knowledge from diverse fields, this review ultimately aims to inspire the design of smarter biomaterial systems that can accelerate the clinical translation of ...
Letao Yang +6 more
wiley +1 more source
Spinocerebellar ataxia type 2 with prominent manifestation of dystonia: one case report
ZHAO Ya-nan +3 more
doaj +1 more source
Inferring Fine-Scale Mutation and Recombination Rate Maps in Aye-Ayes (<i>Daubentonia madagascariensis</i>). [PDF]
Soni V +4 more
europepmc +1 more source
Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang +6 more
wiley +1 more source
Identification of pathogenic variants for the development of ultra-long axial length in myopic children. [PDF]
Zhu Y +6 more
europepmc +1 more source
Machine learning for genomic and pedigree prediction in sugarcane [PDF]
Minoru Inamori +7 more
openalex +1 more source
In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo +6 more
wiley +1 more source
Revealing Amur tiger family pedigrees based on age identification using fecal microbiome and kinship analysis. [PDF]
Hu X +11 more
europepmc +1 more source
Optimal
Shohei Noda +6 more
openalex +1 more source

