Results 301 to 310 of about 286,483 (372)

Neutrophil Extracellular Trap Reprograms Cancer Metabolism to Form a Metastatic Niche Promoting Non‐Small Cell Lung Cancer Brain Metastasis

Advanced Science, EarlyView.
This study mainly combines spatial/single‐cell transcriptomics and metabolomics to reveal LOX+ Malig‐5 as NSCLC brain metastasis‐initiating cells, forming a niche with NET‐releasing neutrophils via the NET‐KRT10 axis. The metastatic niche is involved with metabolic reprogramming, with palmitic acid serving as a key metabolite.
Bo Chen, Karrie M. Kiang, Fangkun Liu, Chuntao Li, Xizhe Li, Chen Weiwei, Xin Fu, Gelei Xiao, Jingyi Sun, Erhan Da, Junbo Liao, Hongshu Zhou, Li Meng, Li Zhou, Tao Song, Longbo Zhang, Gilberto Ka‐Kit Leung, Liyang Zhang   +17 more
wiley   +1 more source

Multi-task genomic prediction using gated residual variable selection neural networks. [PDF]

BMC Bioinformatics
Fan Y, Waldmann P.
europepmc   +1 more source

Mesenchymal Stem Cell‐Derived Extracellular Vesicles Modulate the Course of Peritoneal Inflammation Through Metabolic and Epigenetic Regulation

Advanced Science, EarlyView.
MSC‐EVs alleviate peritoneal inflammation and fibrogenesis by disrupting the H3K18la‐CCL2 axis and crosstalk between mesothelial cells and Ly6c2⁺ macrophages. Model cartoons are constructed using the Biorender website (https://www.biorender.com/), and a usage license is obtained. Abstract Peritoneal dialysis (PD), as a renal replacement therapy, relies
Qiang Huang, Yuxiang Sun, Pengpeng Kuang, Juan Sun, Dandan Guo, Long Peng, Hu Zhou, Qinrong Song, Zhihao Huo, Canming Li, Janusz Witowski, Zhaoyong Hu, Hui Peng   +12 more
wiley   +1 more source

Modular inflammation network discovery from large-scale phenotypic screening in genetically heterogeneous mouse brains. [PDF]

J Neuroinflammation
Xiong M, Miosge LA, Correa-Ospina C, Yan CMY, Cripps T, Bauernfried S, Wang Y, Crow M, Morris LX, Andrews TD, Trujillo A, Rezzonico MG, Liang Y, Bei Q, Modrusan Z, Stark KL, Yuen TJ, Friedman BA, Hanson JE, Bertram EM, Bohlen CJ.   +20 more
europepmc   +1 more source

Dynamic Fibrous Hydrogels for Stem Cell Homing and In Situ Bone Regeneration

Advanced Science, EarlyView.
A dynamic fibrous hydrogel (DFH) is developed by covalent crosslinking of gelatin with tea‐derived trichomes, which integrates the structural and compositional fidelity of native extracellular matrix with photothermal and oxidative responsiveness, introducing a novel “stem cell recruits stem cell” strategy that orchestrates co‐homing of endogenous and ...
Jianmei Chen, Meiling Su, Xinyu Wu, Hongyu Wu, Haotian Wu, Pinghu Zhang, Xueying An, Zongguang Liu   +7 more
wiley   +1 more source

Sorsby Fundus Dystrophy in an Asian Pedigree: Pathogenic Timp3 P.Y191c Variant Impairs Its Binding with Mmp2/9 and Cellular Localization. [PDF]

Clin Ophthalmol
Li M, Peng H, Ding S, Wei Y, Zhang L, Zhou Z, Tang H, Shi P, Liang Y, Li G, Tao Y, Song Z.   +11 more
europepmc   +1 more source

Ocular Abnormalities in 127 Cats Presented for Companion Animal Eye Registry (CAER) Examination in the United States and Canada. [PDF]

Vet Ophthalmol
Collins EC, Diehl KA.
europepmc   +1 more source

Implementing integrated genomic risk assessments for breast cancer: lessons learned from the Electronic Medical Records and Genomics study. [PDF]

JAMIA Open
Liu C, Crew KD, Morse J, Linder JE, Antoniou AC, Carver T, Cortopassi J, Peterson JF, Ta CN, Hoell C, Prows C, Kenny EE, Miller E, Perez E, Jarvik GP, Bland HT, Odgis JA, Mittendorf KF, Bonini KE, McGuffin K, Kottyan LC, Maradik M, Limdi N, Abul-Husn NS, Marathe PN, Suckiel SA, Aguilar S, Lewis TJ, Wei WQ, Luo Y, Freimuth RR, Hakonarson H, Weng C, Chung WK, Wiesner GL.   +34 more
europepmc   +1 more source