Results 71 to 80 of about 22,844 (195)

WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis

open access: yesAdvanced Science, EarlyView.
Upregulated TRMT6 forms aberrant hypermethylation of a specific tRNA pool and serves as a predictor of poor prognosis in TNBC. This m1A modification in tRNAs enhances translation of FTH1 and FTL, reducing the pool of bioavailable Fe2⁺. Reduced Fe2+ availability impairs RSL3‐induced lipid peroxidation and tumor progression.
Yuqing Lei   +12 more
wiley   +1 more source

On Repairing Reasoning Reversals via Representational Refinements [PDF]

open access: yes, 2006
Representation is a fluent. A mismatch between the real world and an agent’s representation of it can be signalled by unexpected failures (or successes) of the agent’s reasoning. The ‘real world ’ may include the ontologies of other agents.
Bundy, Alan   +2 more
core   +2 more sources

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

open access: yesAdvanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang   +12 more
wiley   +1 more source

Calvin Massey, Gentleman Farmer [PDF]

open access: yes, 2017
[Excerpt] “So much of Calvin’s work was intelligible as work about freedom and independence, preventing aggregations of government power that threatened individual freedom. Calvin didn’t love federalism because he had a romanticized view of statehood, he
Lee, Evan Tsen
core   +3 more sources

A survey of the material and intellectual consequences of trading in undocumented ancient coins : a case study on the North American trade [PDF]

open access: yes, 2008
Ancient coins are among the most widely collected and demanded objects among American collectors of antiquities. A vocal lobby of ancient coin dealers/collectors has arisen to protect the importation of undocumented material into the United States and ...
Elkins, Nathan T.
core  

BRS 336: A high-quality fiber upland cotton cultivar for Brazilian savanna and semi-arid conditions. [PDF]

open access: yes, 2012
Cotton cultivar BRS 336 is a high-quality fiber upland cultivar and has wide adaptation to the Brazilian growing areas, with resistance to bacterial blight. BRS 336 exhibited fiber length higher than 32.0 mm in all field tests.
ANDRADE, F. P. de   +10 more
core  

Compound heterozygote myocilin mutations in a pedigree with high prevalence of primary open-angle glaucoma [PDF]

open access: yes, 2012
This article is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 3.0, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited,
Burdon, Kathryn Penelope   +6 more
core  

Kate's Model Verification Tools [PDF]

open access: yes, 1991
Kennedy Space Center's Knowledge-based Autonomous Test Engineer (KATE) is capable of monitoring electromechanical systems, diagnosing their errors, and even repairing them when they crash.
Morgan, Steve
core   +1 more source

Breeding Quality Protein Maize (QPM): Protocols for Developing QPM Cultivars [PDF]

open access: yes
This manual is intended for maize breeders who would like to start developing quality protein maize (QPM) cultivars. It is a compilation and consolidation of several breeding protocols successfully used at CIMMYT over two decades of QPM development and ...
Diallo, Alpha O.   +4 more
core   +1 more source

Rocketdyne/Westinghouse nuclear thermal rocket engine modeling [PDF]

open access: yes
The topics are presented in viewgraph form and include the following: systems approach needed for nuclear thermal rocket (NTR) design optimization; generic NTR engine power balance codes; rocketdyne nuclear thermal system code; software capabilities ...
Glass, James F.
core   +1 more source

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