Results 121 to 130 of about 181,308 (201)

Structural and epistatic regulatory variants cause hallmark white spotting in cattle. [PDF]

Sci Adv
Jivanji S, Wilkinson E, Tang L, Tiplady KM, Yeates A, Harland C, Gray C, Couldrey C, Worth G, Gamache I, Desjardins J, Tabares JAA, Yamanaka N, McNaughton L, Brennan L, Cloutier MP, Cowan M, Ellison R, Fransen T, Monehan T, Spelman RJ, Snell RG, Charlier C, Yamanaka Y, Garrick D, Mort R, Littlejohn MD.   +26 more
europepmc   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

Raman Analysis of RNA Nucleotide Strands From SARS‐CoV‐2 Variants and Subvariants: A Step Forward in the Definition of “Raman Genome”

Advanced Science, EarlyView.
Main Raman signals in RNA, related to helical backbone, ribofuranose ring, and nitrogenous bases, are affected by secondary structures that cause hyperchromic effects and significantly alter the Raman intensity. ABSTRACT Raman spectra of RNA nucleotide strands extracted from 20 SARS‐CoV‐2 strains, including the original Japanese isolate, Alpha, Beta ...
Giuseppe Pezzotti, Yoshiki Yasukochi, Gianluca Angiola, Takaharu Ueno, Saki Ikegami, Rintaro Okawa, Tetsuya Adachi, Wenliang Zhu, Osam Mazda, Alfio Grillo, Koichiro Higasa, Kazu Okuma   +11 more
wiley   +1 more source

Late History of Cattle Breeds in Central Europe in Light of Genetic and Archaeogenetic Sources-Overview, Thoughts, and Perspectives. [PDF]

Animals (Basel)
Janák V, Novák K, Kyselý R.
europepmc   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Variable kinship patterns in Neolithic Anatolia revealed by ancient genomes.

Curr Biol, 2021
Yaka R, Mapelli I, Kaptan D, Doğu A, Chyleński M, Erdal ÖD, Koptekin D, Vural KB, Bayliss A, Mazzucato C, Fer E, Çokoğlu SS, Lagerholm VK, Krzewińska M, Karamurat C, Gemici HC, Sevkar A, Dağtaş ND, Kılınç GM, Adams D, Munters AR, Sağlıcan E, Milella M, Schotsmans EMJ, Yurtman E, Çetin M, Yorulmaz S, Altınışık NE, Ghalichi A, Juras A, Bilgin CC, Günther T, Storå J, Jakobsson M, de Kleijn M, Mustafaoğlu G, Fairbairn A, Pearson J, Togan İ, Kayacan N, Marciniak A, Larsen CS, Hodder I, Atakuman Ç, Pilloud M, Sürer E, Gerritsen F, Özbal R, Baird D, Erdal YS, Duru G, Özbaşaran M, Haddow SD, Knüsel CJ, Götherström A, Özer F, Somel M.   +56 more
europepmc   +1 more source

A de novo frameshift mutation in ZEB2 causes polledness, abnormal skull shape, small body stature and subfertility in Fleckvieh cattle. [PDF]

Sci Rep, 2020
Gehrke LJ, Upadhyay M, Heidrich K, Kunz E, Klaus-Halla D, Weber F, Zerbe H, Seichter D, Graf A, Krebs S, Blum H, Capitan A, Thaller G, Medugorac I.   +13 more
europepmc   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

Mapping Plastic and Plastic Additive Cycles in Coastal Countries: A Norwegian Case Study. [PDF]

Environ Sci Technol
Marhoon A, Hernandez MLH, Billy RG, Müller DB, Verones F.   +4 more
europepmc   +1 more source