Results 71 to 80 of about 9,370 (221)

Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis

Advanced Science, EarlyView.
ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai, Mingchao Zhang, Le Liu, Lide Tao, Chenyang Xu, Hao Chai, Xin Shi, Yin Wang, Xiaopei Zhang, Qiong Chen, Dong Liu, Jinyu Bai, Chang She, Xiaozhong Zhou, Cong Cao, Huajian Shan   +15 more
wiley   +1 more source

Tracing the Origin of the RSPO2 Long-Hair Allele and Epistatic Interaction between FGF5 and RSPO2 in Sapsaree Dog. [PDF]

Genes (Basel), 2022
Kang M, Ahn B, Youk S, Lee YM, Kim JJ, Ha JH, Park C.   +6 more
europepmc   +1 more source

Rebellious uniform [PDF]

, 2012
In this thesis, I focus on adolescent teens at Kingswood College High School, where I am currently employed as a student assistant in Grahamstown. I form part of a networked hierarchy at Kingswood College whereby I am expected to perform duties which ...
Farmer, Mark Ross
core   +1 more source

The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation

Advanced Science, EarlyView.
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley   +1 more source

One Hundred Years of Coat Colour Influences on Genetic Diversity in the Process of Development of a Composite Horse Breed. [PDF]

Vet Sci, 2022
Marín Navas C, Delgado Bermejo JV, McLean AK, León Jurado JM, Torres ARBYR, Navas González FJ.   +5 more
europepmc   +1 more source

Review of Daniel Bryant, 'The Great Recreation: Ho Ching-ming (1483-1521) and His World' [PDF]

, 2009
Tan, Tian Yuan
core   +1 more source

Mothers of Future Kings: The Madonna Redux Phenomenon [PDF]

, 2013
The visual culture that created Diana was motivated by Victorian constrictions of motherhood that enforced notions of stability and lineage. This article examines the cultural metaphors of nurturance – the “Madonna redux phenomenon” – in images of Diana,
Denney, Colleen
core   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

The genetic legacy of African Americans from Catoctin Furnace. [PDF]

Science, 2023
Harney É, Micheletti S, Bruwelheide KS, Freyman WA, Bryc K, Akbari A, Jewett E, Comer E, Gates HL, Heywood L, Thornton J, Curry R, Esselmann SA, Barca KG, Sedig J, Sirak K, Olalde I, Adamski N, Bernardos R, Broomandkhoshbacht N, Ferry M, Qiu L, Stewardson K, Workman JN, Zalzala F, Mallick S, Micco A, Mah M, Zhang Z, 23andMe Research Team†, Rohland N, Mountain JL, Owsley DW, Reich D, 23andMe Research Team.   +34 more
europepmc   +1 more source

A Hall For Hercules At Ostia And A Farewell To The Late Antique >Pagan Revival> [PDF]

, 2010
In 1945, Herbert Bloch published an inscription from Ostia recording the restoration of a cellam Herc[ulis] in the late fourth century and suggested that it heralded the last pagan revival in the western Roman empire.
Boin, Douglas R.
core