Results 71 to 80 of about 2,220,924 (319)
FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots
FEBS Letters, EarlyView.This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino +7 more
wiley +1 more source
Efficient and Effective Use of Peer Teaching for Medical Student Simulation
Western Journal of Emergency Medicine, 2017 Simulation is increasingly used in medical education, promoting active learning and retention; however, increasing use also requires considerable instructor resources.
House, Joseph +5 more
doaj +1 more source
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
Scalable Peer-to-Peer Indexing with Constant State [PDF]
, 2002 We present a distributed indexing scheme for peer to peer networks. Past work on distributed indexing traded off fast search times with non-constant degree topologies or network-unfriendly behavior such as flooding.
Considine, Jeffrey, Florio, Thomas A.
core
Fault-tolerant routing in peer-to-peer systems
, 2002 We consider the problem of designing an overlay network and routing mechanism that permits finding resources efficiently in a peer-to-peer system. We argue that many existing approaches to this problem can be modeled as the construction of a random graph
Aspnes, James, Diamadi, Zoe, Shah, Gauri
core +5 more sources
Peer-Assisted Information-Centric Network (PICN): A Backward Compatible Solution
IEEE Access, 2017 Information-centric networking (ICN) is a promising solution for most of Internet applications where the content represents the core of the application.
Zeinab Zali +4 more
doaj +1 more source
FEBS Letters, EarlyView.Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello +6 more
wiley +1 more source
Symmetric Replication for Structured Peer-to-Peer Systems [PDF]
, 2005 Structured peer-to-peer systems rely on replication as a basic means to provide fault-tolerance in presence of high churn. Most select replicas using either multiple hash functions, successor-lists, or leaf-sets.
Ghodsi, Ali +2 more
core +2 more sources
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source