Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Parallelisation for data-intensive applications over peer-to-peer networks [PDF]
In Data Intensive Computing, properties of the data that are the input for an application decide running performance in most cases. Those properties include the size of the data, the relationships inside data, and so forth.
Chen, Xinuo
core
Pay It Forward: Analysis of a novel peer-to-peer support initiative for individuals receiving treatment for head and neck cancer. [PDF]
Support Care CancerMason M +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Blockchain consensus mechanism and method for peer-to-peer electricity trading. [PDF]
Sci RepWang N, Chen Y, Zhai F, Li B.
europepmc +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Perceived barriers and facilitators to the feasibility and acceptability of a peer-to-peer (P2P) HIV self-testing distribution model among adolescents and young people aged 15-24 years in Uganda: a qualitative study. [PDF]
BMJ Public HealthNdekezi D +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Implementation and evaluation of a peer-to-peer support program in oncology: study protocol for the PaRole Onco France model. [PDF]
Arch Public HealthBusnel Y +13 more
europepmc +1 more source