Results 71 to 80 of about 530,627 (295)

Virtual cluster scheduling through the scheduling graph [PDF]

, 2007
This paper presents an instruction scheduling and cluster assignment approach for clustered processors. The proposed technique makes use of a novel representation named the scheduling graph which describes all possible schedules.
Codina Viñas, Josep M., González Colás, Antonio María, Sánchez Navarro, Jesús   +2 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Response switching and self-efficacy in Peer Instruction classrooms

Physical Review Special Topics. Physics Education Research, 2015
Peer Instruction, a well-known student-centered teaching method, engages students during class through structured, frequent questioning and is often facilitated by classroom response systems.
Kelly Miller, Julie Schell, Andrew Ho, Brian Lukoff, Eric Mazur   +4 more
doaj   +1 more source

Characterizing active learning environments in physics using network analysis and classroom observations

Physical Review Physics Education Research, 2021
This study uses social network analysis and the classroom observation protocol for undergraduate STEM (COPUS) to characterize six research-based introductory physics curricula. Peer Instruction, Modeling Instruction, ISLE, SCALE-UP, Context-Rich Problems,
Kelley Commeford, Eric Brewe, Adrienne Traxler   +2 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Use of Clinical Cases to Teach Endocrine Physiology by means of Peer Instruction and via the Socrative app

Revista Cubana de Investigaciones Biomédicas, 2020
Introduction: The peer instruction methodology promotes the consolidation of concepts through discussions by the students when they are asked to solve clinical cases or to answer questions elaborated by the teacher.
Maria José Alves da Rocha, José Caetano de Souza   +1 more
doaj  

INTEGRASI STRATEGI PEER INSTRUCTION KE DALAM MODEL PEMBELAJARAN LEARNING CYCLE 7EUNTUK MENINGKATKAN PEMAHAMAN MATERI AJAR DAN PENALARAN ILMIAH SISWA SMA [PDF]

, 2016
Pembelajaran fisika harus menjadikan pebelajar memiliki kemampuan memahami materi ajar dan penalaran ilmiah yang sangat diperlukan dalam kemajuan sains di Indonesia.
Suparna, Iip
core  

Peer assessment as collaborative learning [PDF]

, 2010
Peer assessment is an important component of a more participatory culture of learning. The articles collected in this special issue constitute a representative kaleidoscope of current research on peer assessment.
Aleven, Andriessen, Cho, Clark, Frank Fischer, Gielen, Graesser, Hattie, Hayes, Ingo Kollar, King, King, Kollar, Leitão, Nastasi, Oser, Quintana, Renkl, Schoenfeld, Strijbos, Strijbos, Strijbos, Van der Pol, Van Gennip, Van Steendam, Van Zundert, Webb, Webb   +27 more
core   +3 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source