Results 41 to 50 of about 1,123,819 (291)

Identity formation in Proverbs 22 and the Mkpuru Mmiri drug crisis in Igbo communities

open access: yesHTS Teologiese Studies/Theological Studies, 2022
Although progress, no matter how small, has been made by scholars who examined different aspects of the Mkpuru Mmiri [methamphetamine or crystal meth] drug crisis in Nigerian Igbo communities, literature is yet to approach the study from the perspective ...
Favour C. Uroko
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Perceptions of church leaders on accessibility and affordability of alcohol abuse amongst youth in Musina Town, Limpopo province

open access: yesTheologia Viatorum, 2019
Alcohol abuse is associated with numerous risk factors amongst the youth. The youth indulge in binge drinking because of social exclusion, and accessibility and affordability of alcohol, especially in rural areas.
Frans K. Matlakala, Jabulani Makhubele
doaj   +1 more source

Interpersonal and intrapersonal differences among adolescent nonsmokers, ex-smokers, and smokers [PDF]

open access: yes, 2017
Background: A large body of research has traced tobacco dependence among adolescents to a series of intrapersonal and interpersonal factors. However, there are remaining questions regarding the differences on these factors related to tobacco use ...
Baiocco, Roberto   +5 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

AN INVESTIGATION INTO CAREER DECISION-MAKING AMONG FINAL YEAR PRIMARY SCHOOL STUDENTS IN IBADAN [PDF]

open access: yesSocial Sciences and Education Research Review
This study investigated the influence of self-efficacy, peer pressure, and social media on the career decision-making processes of final-year primary school pupils in Ibadan.
Adewuyi Habeeb OMOPONLE
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Unshackling our youth from the chains of substance abuse as disaster risk

open access: yesFrontiers in Public Health
This study, a collaboration between the University of Limpopo and the Human Sciences Research Council (HSRC), aimed to generate baseline evidence to inform the development of an innovative performative arts intervention, designed to engage young people ...
Konosoang Sobane   +7 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

A multi-dataset exploratory framework for understanding digital behavior and substance use risk profiles

open access: yesFrontiers in Public Health
IntroductionSubstance use continues to evolve as a multidimensional public health challenge influenced by traditional behavioral triggers and emerging digital interactions.
Perla Shiva Sindhu, Modigari Narendra
doaj   +1 more source

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