Results 151 to 160 of about 6,365,430 (326)

Geometrical Designs in Volumetric Bioprinting to Study Cellular Behaviors in Engineered Constructs

Advanced Healthcare Materials, EarlyView.
Curvature and spatial confinement guide cell behavior in volumetrically printed 3D constructs. Endothelial cells align and spread along specific geometries, while metastatic osteosarcoma cells proliferate independently of structural cues. Label‐free holographic microscopy captures real‐time, long‐term cell–material interactions, highlighting Gel‐PEG's ...
Julia Simińska‐Stanny, Pierre Tournier, Armin Shavandi, Shukry J Habib   +3 more
wiley   +1 more source

Rheological Properties of Hemoglobin-Based Physical and Chemical Gels, and Their Hybrid. [PDF]

ACS Omega
Matsuhira T, Sakai H.
europepmc   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Folate-targeted gold nanoparticles for doxorubicin delivery in tumor spheroids. [PDF]

Drug Deliv
Daniele R, Fragassi A, Pesce C, Tognetti F, Verona M, Marzaro G, Salmaso S, Caliceti P.   +7 more
europepmc   +1 more source

Photosensitizing Lipid Nanoparticles for Ferroptosis‐Enhanced Photodynamic Cancer Therapy via GPX4 Silencing

Advanced Healthcare Materials, EarlyView.
Photosensitizing lipid nanoparticles (PLNPs) are engineered by incorporating cholesterol–PEG–pheophorbide a into MC3‐based LNPs and encapsulating GPX4‐targeting siRNA. Upon light activation, PLNPs generate reactive oxygen species (ROS) while silencing GPX4 to induce ferroptosis.
Ga‐Hyun Bae, Seungyong Shin, Joo Dong Park, Eun‐Young Koh, Seunghyo Ko, Jieun Han, Chun Gown Park, Dong‐Hyun Kim, Kun Na, Wooram Park   +9 more
wiley   +1 more source

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

Spleen-targeted mRNA delivery via long-chain PEGylated lipids at low molar ratio enhances antitumor immunity against melanoma. [PDF]

Mol Ther Nucleic Acids
Liu S, Zhang L, Wu W, Chen MY, Qian F.
europepmc   +1 more source

The Effect of N/P Ratio on the In Vitro and In Vivo Interaction Properties of PEGylated Poly[2‐(dimethylamino)ethyl methacrylate]‐Based siRNA Complexes

, 2013
Dana J. Gary, Jungbin Min, Young-Wook Kim, Keunchil Park, You‐Yeon Won   +4 more
openalex   +1 more source

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Optimizing Surface Functionalization for Aptameric Graphene Nanosensors in Undiluted Physiological Media. [PDF]

Sensors (Basel)
Dai W, Wang Z, Yu S, Wen K, Yang Y, Lin Q.   +5 more
europepmc   +1 more source