Results 161 to 170 of about 6,365,430 (326)

Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics

Advanced Healthcare Materials, EarlyView.
A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Carolyn M. Watkins, Samuel L. Hallam, Mariah J. Austin, Adrianne M. Rosales   +3 more
wiley   +1 more source

Highly Tunable and Cell‐Remodelable Thiol‐ene Alginate‐Peptide Crosslinked Hydrogels to Recreate Cellular and Organoid Microenvironments for Biofabrication

Advanced Healthcare Materials, EarlyView.
Norbornene‐functionalized alginate is crosslinked with a di‐thiolated peptide sequence cleavable by cell‐secreted matrix metalloproteinases and decorated with cell‐adhesion peptides upon exposure to UV. Thyroid follicles, endometrial and intestinal organoids are encapsulated in a gentle manner with high cell viability and correct phenotype ...
Julia Fernández‐Pérez, Adrián Seijas‐Gamardo, Antonio J. Feliciano, Panagiota Kakni, Anna M. Kip, Paul Wieringa, Stefan Giselbrecht, Matthew B. Baker, Lorenzo Moroni   +8 more
wiley   +1 more source

Folate-Functionalized Polymeric Nanoparticles for 5‑Fluorouracil Delivery to Prostate Cancer: Physicochemical and In Vitro/In Vivo Characterization. [PDF]

ACS Omega
Bhatt B, Kalyankar G, Vyas B, Lalan M, Desai N, Vora LK, Shah P.   +6 more
europepmc   +1 more source

Dual‐Functional Polyphosphoesters for Gene Delivery: Synergistic Effects of Guanidinium and Hydrophobic Side Chains in Degradable Polymers

Advanced Healthcare Materials, EarlyView.
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Markus Kötzsche, Andreas Dzierza, Jan Egger, Timo Rheinberger, Christin Weilandt, Frederik R. Wurm, Ivo Nischang, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

3D-Printed Poly(lactic acid)/Poly(ethylene glycol) Scaffolds with Shape-Memory Effect near Physiological Temperature. [PDF]

Polymers (Basel)
Fetisova AA, Bin Firoz A, Lozhkomoev AS, Senkina EI, Ryumin EE, Surmeneva MA, Surmenev RA.   +6 more
europepmc   +1 more source

Impact of PEG-lipid structure and molar ratio on the physicochemical and efficacy of pDNA- and mRNA-LNPs

Gabriel Vieira Azevedo, Marco Túllio Rodrigues Alves, Pedro Henrique Dias Moura Prazeres, Gabriel Henrique Costa da Silva, Letícia Helena Fernandes Fujii, Pedro Pires Goulart Guimarães   +5 more
openalex   +1 more source

The role of the ratio (PEG:PPG) of a triblock copolymer (PPG‐ b ‐PEG‐ b ‐PPG) in the cure kinetics, miscibility and thermal and mechanical properties in an epoxy matrix

, 2018
Bruna Louise Silva, Roger Hoel Bello, Luiz Antônio Ferreira Coelho   +2 more
openalex   +2 more sources

Influence of the Long-Chain/Short-Chain Amphiphile Ratio on Lateral Diffusion of PEG-Lipid in Magnetically Aligned Lipid Bilayers as Measured via Pulsed-Field-Gradient NMR [PDF]

, 2005
Ronald Soong, Peter M. Macdonald
openalex   +1 more source

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

Spatial Heterogeneity of Metabolic Response to Drought Stress in <i>Medicago lupulina</i> L. Leaves. [PDF]

Metabolites
Wang X, Lv N, Xu Y, Meng X, Jin Y, Gao H, Li F, Yi Y, Liu L, Shen T.   +9 more
europepmc   +1 more source