Results 191 to 200 of about 6,229,738 (373)

Impact of polyplex micelles installed with cyclic RGD peptide as ligand on gene delivery to vascular lesions [PDF]

, 2010
Gene therapy is expected to open a new strategy for the treatment of refractory vascular diseases, so the development of appropriate gene vectors for vascular lesions is needed. To realize this requirement with a non-viral approach, cyclo(RGDfK) peptide (
Hideo Kagaya, Hiroyuki Koyama, Kazunori Kataoka, Makoto Oba, Takehiko Ishii, Tetsuro Miyata, Tsuyoshi Takato, Yutaka Miura   +7 more
core   +1 more source

Formulation and Characterization of Novel Ionizable and Cationic Lipid Nanoparticles for the Delivery of Splice‐Switching Oligonucleotides

Advanced Materials, EarlyView.
Lipid nanoparticles (LNPs) of unconventional composition and defined structures are investigated as small oligonucleotide carriers. A composition is identified that outperforms Onpattro in cargo delivery to HeLa cells. The structure of these LNPs resembles a micellar cubic phase not commonly associated with high‐performing LNPs.
Miina Ojansivu, Hanna M. G. Barriga, Margaret N. Holme, Stefanie Morf, James J. Doutch, Samir EL Andaloussi, Tomas Kjellman, Markus Johnsson, Justas Barauskas, Molly M. Stevens   +9 more
wiley   +1 more source

Traversing the Periodic Table through Phase‐Separating Nanoreactors

Advanced Materials, EarlyView.
Centimeter‐scale arrays of single nanoparticles, generated through either Dip Pen Nanolithography or Polymer Pen Lithography, allow for the discovery of novel nanomaterials at an unprecedented scale. The development of phase‐separating hydrophobic nanoreactors bypasses element‐specific chemistry limitations, enabling the synthesis of polyelemental ...
Carolin B. Wahl, Jordan H. Swisher, Peter T. Smith, Vinayak P. Dravid, Chad A. Mirkin   +4 more
wiley   +1 more source

Polyethylene glycol versus dual sugar assay for gastrointestinal permeability analysis: is it time to choose?

Clinical and Experimental Gastroenterology, 2012
Kim van Wijck,1,2 Babs AFM Bessems,2 Hans MH van Eijk,2 Wim A Buurman,2 Cornelis HC Dejong,1,2 Kaatje Lenaerts1,21Top Institute Food and Nutrition, Wageningen, The Netherlands; 2Department of Surgery, NUTRIM School for Nutrition, Toxicology and ...
van Wijck K, Bessems BAFM, van Eijk HM, Buurman WA, Dejong CH, Lenaerts K   +5 more
doaj  

Transforming Healthcare: Intelligent Wearable Sensors Empowered by Smart Materials and Artificial Intelligence

Advanced Materials, EarlyView.
Wearable sensors, empowered by AI and smart materials, revolutionize healthcare by enabling intelligent disease diagnosis, personalized therapy, and seamless health monitoring without disrupting daily life. This review explores cutting‐edge advancements in smart materials and AI‐driven technologies that empower wearable sensors for diagnostics and ...
Shuwen Chen, Shicheng Fan, Zheng Qiao, Zixiong Wu, Baobao Lin, Zhijie Li, Michael A. Riegler, Matthew Yu Heng Wong, Arve Opheim, Olga Korostynska, Kaare Magne Nielsen, Thomas Glott, Anne Catrine T. Martinsen, Vibeke H. Telle‐Hansen, Chwee Teck Lim   +14 more
wiley   +1 more source

Solid Polymer Electrolyte with Compatible Cathode‐Electrolyte Interfacial Design Enabling Lithium Metal Batteries Operation at 4.8 V with Long Cycle Life

Advanced Materials, EarlyView.
This study introduce a novel approach to enhancing cathode‐SPE compatibility by utilizing the same poly(ionic liquid) (PolyIL)‐based material in both the SPE and the cathode binder. A modified biomass‐based PolyIL substrate, enriched with highly negatively charged C═O and ─OH groups, is incorporated into the SPE to improve Li+ migration and strengthen ...
Jiajia Li, Haiman Hu, Jiufu Zhu, Xinyu Ma, Yin Hu, Haitao Zhang, Fengming Liu, Suojiang Zhang, Xiaoyan Ji   +8 more
wiley   +1 more source

Decoupling Degradation at the Electrode Interfaces in Prussian White Full Cells

Advanced Materials Interfaces, EarlyView.
Prussian White (PW) as a sodium‐ion battery (SIB) cathode material is advancing, having already been commercialized. Yet, capacity fade and cyanide‐related safety risks persist. By integrating Mössbauer‐ and online electrochemical mass spectrometry, this study analyzes degradation in PW cells, observing hydrogen and cyanide evolution.
Casimir Misiewicz, Alexandra E. Ulander, Tim Melin, Aram Hall, Erik J. Berg   +4 more
wiley   +1 more source

Fast Prototyping and Ex Vivo Evaluation of Dissolvable Millineedle Patches Made by Solvent Casting from CO2 Laser Ablated Elastomer Molds

Advanced Materials Interfaces, EarlyView.
CO2 laser ablation, a fast, inexpensive, and reproducible method, is used to create flexible elastomer molds with millimeter‐long cavities for the fabrication of dissolvable polymer needles. Made from PVP, these milli‐needles achieve ≈560 µm penetration into porcine skin, demonstrating their potential for effective transdermal drug delivery.
Matteo Tollemeto, Lasse Højlund Eklund Thamdrup, Veni Mahalingam, Gavrielle R. Untracht, Tania Patiño Padial, Peter Eskil Andersen, Jan van Hest, Anja Boisen   +7 more
wiley   +1 more source

Exploring DNA Functionalization Techniques for Silver Nanoparticles

Advanced Materials Interfaces, EarlyView.
This study evaluates four functionalization methods—salt‐aging, pH‐assisted, freezing‐directed, and microwave‐assisted—for attaching DNA strands to 20 nm silver nanoparticles (AgNPs). The resulting DNA‐AgNP conjugates are characterized and colloidal stability and DNA loading are assessed.
Sebastian Freko, Marta Nikić, Lennart J.K. Weiß, Bernhard Wolfrum   +3 more
wiley   +1 more source

Comparison of peginterferon alfa-2a and alfa-2b for treatment of patients with chronic hepatitis C:a retrospective study using the Japanese Interferon Database

Drug Design, Development and Therapy, 2014
Izumi Sato,1 Takuro Shimbo,2 Yohei Kawasaki,3 Naohiko Masaki41Department of Clinical Study and Informatics, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan; 2Ohta Nishinouchi Hospital, Fukushima, Japan ...
Sato I, Shimbo T, Kawasaki Y, Masaki N
doaj