Results 291 to 300 of about 7,450,425 (377)

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

Neutrophil‐Driven Cascade‐Targeted Nanocarriers Restore Mitochondrial Homeostasis to Ameliorate Renal Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A neutrophil‐mediated dual‐targeting liposome (NKN‐LNP) is developed to treat renal ischemia–reperfusion injury. The system enables spatiotemporally controlled delivery of NMN to injured tubules via MMP‐2/9 activation and KIM1 recognition, restoring mitochondrial function through NAD+‐SIRT3 signaling and preventing the transition from acute kidney ...
Hangbin Ma, Yang Li, Shen Lin, Feifan Chu, Gaozhan Ren, Yinhui Mao, Mingzhi Wu, Yuning Ma, Qiwei Ji, Zujie Chen, Jinzhong Ji, Mingxin Sun, Yongpeng Xu, Xiaoli Sun, Longguang Tang, Hao Zhou   +15 more
wiley   +1 more source

Polyethylene Glycol Nanocolloids as Advanced Phase Change Materials for Sustainable Energy: Experimental Data on Viscosity, Density, and Isobaric Heat Capacity. [PDF]

Polymers (Basel)
Ţugui CA, Cojocariu N, Pricop B, Bejan D, Minea AA.   +4 more
europepmc   +1 more source

Solamargin-functionalized gold nanoparticles codelivering photothermal-immunotherapy for triple-negative breast cancer. [PDF]

Breast Cancer
Gui Z, Zhao L, Liu S, Zhang L.
europepmc   +1 more source

Dendrimer Nanogels with Built-in Free Radical Scavenging Enable Efficient Topical Delivery of a Hydrophilic Antioxidant to Restore Lens Redox Balance for Cataract Treatment. [PDF]

ACS Appl Mater Interfaces
Qi L, Kou H, Chernatynskaya A, Huang D, Mani VJ, Karacal H, Ercal N, Yang H.   +7 more
europepmc   +1 more source

2',5'-oligoadenylate synthetase response ratio predicting virological response to PEG-interferon-α2b plus ribavirin therapy in patients with chronic hepatitis C

, 2008
啓二 金
openalex   +1 more source

Selective mRNA Delivery to Activated Macrophages via Hyaluronic Acid-Functionalized Lipid Nanoparticles with Optimized PEGylation. [PDF]

Biomacromolecules
Cao M, Fay F, Hotier A, Domenichini S, Alexandre L, Ribes C, Gazeau F, Hillaireau H, Fattal E.   +8 more
europepmc   +1 more source

Triphenylphosphine bromide enhances the effect of nano-micellar drug delivery system loaded with ROS inhibitor TEMPO on acute lung injury. [PDF]

J Biol Eng
Wang J, Xu L, Li W, Zhao F, Yang Y, Shan L, Xin L, Wang W.   +7 more
europepmc   +1 more source

Weekly pegylated recombinant human growth hormone for prepubertal children with growth hormone deficiency: adherence advantage drives superior short-term efficacy over daily rhGH. [PDF]

Transl Pediatr
Guo H, Zhai Y, Yaheyajiang A, Mohemai Z, Liu L, Zheng L, Tuniyazi K.   +6 more
europepmc   +1 more source