Results 71 to 80 of about 7,450,425 (377)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

The effect of temperature on the synthesis and characterization of hydroxyapatite-polyethylene glycol composites by in-situ process

Hybrid Advances, 2023
Hydroxyapatite (HAp) is a vital material in various biomaterials but has low flexibility. Because of that, research has been done to increase the efficiency of hydroxyapatite by combining it with polyethylene glycol (PEG).
Novesar Jamarun, Dinda Amelia, Rahmayeni, Upita Septiani, Vivi Sisca   +4 more
doaj   +1 more source

Self-healing metallo-supramolecular hydrogel based on specific Ni2+ coordination interactions of poly(ethylene glycol) with bistriazole pyridine ligands in the main chain [PDF]

, 2020
In this study, a supramolecular hydrogel formed by incorporating the 2,6-bis(1,2,3-triazol-4-yl)-pyridine (btp) ligand in the backbone of a polymer prepared by copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) "click" polyaddition reaction of 2,6 ...
Hoogenboom, Richard, Jerca, Valentin-Victor, Xu, Xiaowen   +2 more
core   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Au@CuS Nanoshells for Surface-Enhanced Raman Scattering Image-Guided Tumor Photothermal Therapy with Accelerated Hepatobiliary Excretion

Pharmaceutics
Gold-based nanoparticles for surface-enhanced Raman scattering (SERS) imaging show great potential for precise tumor detection and photothermal therapy (PTT). However, the metabolizability of gold nanoparticles (Au NPs) raises big concerns.
Sihang Zhang, Sheng Yu, Jingwen Sun, Teng Huang, Hongzheng Lin, Zhe Li, Zeyu Xiao, Wei Lu   +7 more
doaj   +1 more source

Evidence for a spectroscopic direct detection of reflected light from 51 Peg b

, 2015
The detection of reflected light from an exoplanet is a difficult technical challenge at optical wavelengths. Even though this signal is expected to replicate the stellar signal, not only is it several orders of magnitude fainter, but it is also hidden ...
Boisse, I., Cunha, D., Ehrenreich, D., Faria, J. P., Figueira, P., Lovis, C., Martins, J. H. C., Mayor, M., Melo, C., Montalto, M., Pepe, F., Santos, N. C., Sousa, S. G., Udry, S.   +13 more
core   +3 more sources

High performance shape memory polyurethane synthesized with high molecular weight polyol as the soft segment [PDF]

, 2012
Shape memory polyurethanes (SMPUs) are typically synthesized using polyols of low molecular weight (MW~2,000 g/mol) as it is believed that the high density of cross-links in these low molecular weight polyols are essential for high mechanical strength ...
Ahmad, Manzoor, Fu, Richard, Huang, Wei Min, Luo, Jikui, Miraftab, Mohsen, Purnawali, Hendra, Xu, Bin   +6 more
core   +2 more sources

Synthesis of a Novel Thermoresponsive S53P4 Bioactive Glass Extract–Poloxamer 407 Injectable Hydrogels: Assessment of Biocompatibility and Antimicrobial Properties

Advanced Engineering Materials, EarlyView.
This study investigates innovative thermoreversible hydrogels derived from S53P4 bioactive glass extracts to aid in the healing of infected diabetic foot wounds. These injectable gels, which gel at body temperature, release beneficial ions and remain stable over time.
Marian G. Vargas Guerrero, Adrian Stiller, Alex Nygård, Matej Krivulka, Lars Galema, Erwin Peters, Jimmy Lucchesi, Peter Uppstu, Leena Hupa, Jacobus J. C. Arts   +9 more
wiley   +1 more source

Artificial Extracellular Matrix Proteins Containing Phenylalanine Analogues Biosynthesized in Bacteria Using T7 Expression System and the PEGylation [PDF]

, 2011
In vivo incorporation of phenylalanine (Phe) analogues into an artificial extracellular matrix protein (aECM-CS5-ELF) was accomplished using a bacterial expression host that harbors the mutant phenylalanyl-tRNA synthetase (PheRS) with an enlarged binding
Furukawa, Yuya, Higuchi, Masahiro, Ito, Akihiro, Kinoshita, Takatoshi, Kondo, Shiori, Kwon, Inchan, Takasu, Akinori   +6 more
core   +2 more sources

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source