Results 41 to 50 of about 107,041 (362)

Association of cigarette smoking habits with the risk of prostate cancer: a systematic review and meta-analysis

BMC Public Health, 2023
Background Association of cigarette smoking habits with the risk of prostate cancer is still a matter of debate. This systematic review and meta-analysis aimed to assess the association between cigarette smoking and prostate cancer risk.
Xiangwei Yang, Hong Chen, Shiqiang Zhang, Xianju Chen, Yiyu Sheng, Jun Pang   +5 more
doaj   +1 more source

Pubic bone injuries in primiparous women: magnetic resonance imaging in detection and differential diagnosis of structural injury [PDF]

, 2012
Objective To evaluate the utility of magnetic resonance imaging (MRI) in diagnosing structural injury in primiparous women at risk for pelvic floor injury.
Ashton-Miller, Aslan, Barnes, Boks, Boks, Brandon, Brennan, Christianson, Cunningham, Datir, DeLancey, DeLancey, Diamond, Dietz, Dietz, Garagiola, Hayat, Hermann, Kearney, Kiuru, Leadbetter, Lien, Maldjian, Mayerhoefer, Miller, Novellas, Shek, Verrall, Verrall, Wurdinger, Zajick, Zoga   +31 more
core   +1 more source

Observation on the clinical effectiveness of intermuscular suture combined with fullthickness advancement flap in the treatment of suprasphincteric anal fistula: a series of 33 cases

结直肠肛门外科
[Objectives] To investigate the clinical effectiveness of intermuscular suture combined with full-thickness advancement flap in the treatment of suprasphincteric anal fistula.
Yang Xiaoyuan, Chen Wenping, Lin Wanlin, Ma Qiaoling, Zhang Lei, Zhu Jiandong, Zhao Shen, Yang Limin, Ma Zhiteng, Huang Shaoling, Yuan Yuewen   +10 more
doaj   +1 more source

The dynamic cellular and molecular features during the development of radiation proctitis revealed by transcriptomic profiling in mice

BMC Genomics, 2022
Background Radiation proctitis (RP) is the most common complication of radiotherapy for pelvic tumor. Currently there is a lack of effective clinical treatment and its underlying mechanism is poorly understood.
Qingzhi Zeng, Jingyang Cheng, Haiyong Wu, Wenfeng Liang, Yanmei Cui   +4 more
doaj   +1 more source

Intimate communications within the tumor microenvironment: stromal factors function as an orchestra

Journal of Biomedical Science, 2023
Extensive studies of the tumor microenvironment (TME) in the last decade have reformed the view of cancer as a tumor cell-centric disease. The tumor microenvironment, especially termed the "seed and soil" theory, has emerged as the key determinant in ...
Bing Cheng, Qiang Yu, Wenyu Wang
doaj   +1 more source

ACSS2‐Mediated Histone H4 Lysine 12 Crotonylation (H4K12cr) Alleviates Colitis via Enhancing Transcription of CLDN7

Advanced Science, EarlyView.
Histone lysine crotonylation (Kcr) is a highly conserved posttranslational modification implicated with crucial biological processes. This study reveals that ACSS2‐mediated H4K12cr upregulated CLDN7 transcription to strengthen intestinal epithelial barrier.
Ming Yuan, Shaopeng Chen, Zhensen Lin, Runfeng Yu, Kang Chao, Shubiao Ye, Qing Li, Haoxian Ke, Chi Zhang, Junfeng Huang, Guanzhan Liang, Tuo Hu, Xiang Gao, Ping Lan, Xianrui Wu   +14 more
wiley   +1 more source

Which Way to Choose for the Treatment of Metastatic Prostate Cancer: A Case Report and Literature Review

Frontiers in Oncology, 2021
BackgroundProstate cancer (PCa) is the second most common cancer among males in the world and the majority of patients will eventually progress to the metastatic phase. How to choose an effective way for the treatment of metastatic PCa, especially in the
Xiangwei Yang, Donggen Jiang, Yamei Li, Tianzhi Zhang, Duanya Xu, Xianju Chen, Jun Pang   +6 more
doaj   +1 more source

Uncovering changes in proteomic signature of rat pelvic floor muscles in pregnancy. [PDF]

, 2019
BackgroundStructural and functional changes of the rat pelvic floor muscles during pregnancy, specifically, sarcomerogenesis, increase in extracellular matrix content, and higher passive tension at larger strains protect the integral muscle components ...
Alperin, Marianna, Boscolo, Francesca Sesillo, Burnett, Lindsey A, Laurent, Louise C, Wong, Michelle   +4 more
core   +1 more source

Individualised pelvic floor muscle training in women with pelvic organ prolapse: a multicentre randomised controlled trial [PDF]

, 2013
<br>Background: Pelvic organ prolapse is common and is strongly associated with childbirth and increasing age. Women with prolapsed are often advised to do pelvic floor muscle exercises, but supporting evidence is limited.
Barry, Sarah, Dickson, Sylvia, Elders, Andrew, Frawley, Helena, Galea, Mary P, Glazener, Cathryn, Hagen, Suzanne, Logan, Janet, McDonald, Alison, McPherson, Gladys, Moore, Kate H, Norrie, John, POPPY Trial Collaborators, Stark, Diane, Walker, Andrew, Wilson, Don   +15 more
core   +4 more sources

QSOX2‐Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c‐Myc Feedback Loop in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
High QSOX2 enhances stemness, drug resistance, and metastasis of ESCC cells. QSOX2‐mediated disulfide bond modification activates mTOR/c‐Myc signaling. CAFs‐secreted IGF‐1 drives mTOR/c‐Myc/QSOX2 positive feedback loop. Combining Ebselen, rapamycin, and cisplatin induces tumor dormancy in mice.
Wo‐Ming Chen, Xiao‐Ping Zhang, Xiao Sun, Hai‐Cheng Liu, Yuan‐Yuan Yan, Xue Wei, Yu Liang, Yue Feng, Zhengjie Chen, Yongxu Jia, Chen Jiang, Qian Yan, Lei Li   +12 more
wiley   +1 more source