Results 71 to 80 of about 527,539 (306)

SLC25A21 promotes ferroptosis by inducing mitochondrial GPX4 deficiency in colorectal cancer

Cellular and Molecular Life Sciences
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) plays a crucial role in maintaining mitochondrial function and regulating apoptosis. Whether SLC25A21 influences cell death solely through apoptosis remains unclear. Here, we reported that mitochondrial
Wanjun Liu, Wenqing Xie, Minghan Huang, Zhimei Ou, Meihua Wu, Li Lv, Caibin Li, Qianxin Luo, Qian Wang, Ketong Wu, Daici Chen   +10 more
doaj   +1 more source

5-ALA/Fe2+ attenuates testicular inflammatory injury and spermatogenic failure in non-obstructive azoospermia mice by suppressing the TP53-CASP3 apoptotic cascade

Frontiers in Cell and Developmental Biology
BackgroundNon-obstructive azoospermia (NOA) remains a major challenge in the management of male infertility, with currently limited effective therapeutic options available.
Jiewen Zhu, Jiewen Zhu, Jing Zhai, Zhanxin Xu, Zhanxin Xu, Yifan Wang, Yifan Wang, Jinle Xie, Yangyun Wang, Yangyun Wang, Jiangang Hou, Ke Xu, Ke Xu   +12 more
doaj   +1 more source

Human evolution and the obstetrical dilemma: The pelvic floor hypothesis

The Anatomical Record, EarlyView.
Abstract Human childbirth is mechanically difficult because a large‐headed, broad‐shouldered fetus must pass through a comparatively narrow, twisted bony birth canal. Traditional explanations of this “obstetrical dilemma” emphasize the role of bipedal locomotion in inhibiting the evolution of a wider, more spacious pelvis.
Barbara Fischer, Ekaterina Stansfield
wiley   +1 more source

The “costly son” hypothesis: Sons exacerbate obstetrical dilemmas in humans and other mammals

The Anatomical Record, EarlyView.
Abstract Human childbirth has often been considered uniquely difficult among mammals, yet recent evidence suggests that obstructed labor and fetopelvic disproportion are widespread across placental mammals. Here, we propose the “costly son” hypothesis: because male offspring are typically larger at birth, they impose greater obstetric risk on mothers ...
Nicole D. S. Grunstra, Jonathan C. K. Wells   +1 more
wiley   +1 more source

Knowledge, attitudes, and practices of hemorrhoid patients regarding surgical treatment

Scientific Reports
This study aimed to assess the knowledge, attitudes, and practices (KAP) of patients with hemorrhoids concerning surgical treatment. This cross-sectional study was conducted between October 2023 and February 2025 in Chengdu, Sichuan Province, China and ...
Yan Hu, Xihong Wang, Lihong Chen
doaj   +1 more source

Automatic localisation of innervation zones: a simulation study of the external anal sphincter [PDF]

, 2009
Traumas of the innervation zone (IZ) of the external anal sphincter (EAS), e.g. during delivery, can promote the development of faecal incontinence. Recently developed probes allow high-resolution detection of EMG signals from the EAS.
Merletti, Roberto, Gazzoni, Marco, Mesin, Luca   +2 more
core   +1 more source

Pelvic floor muscle training as a method supporting the treatment of pelvic floor dysfunctions in women

, 2021
Objective: Pelvic floor dysfunctions in women are a challenge for the modern health care system. Presentation of the most popular types of pelvic floor muscle training used successfully in women at different stages of their lives.
Monika Englert-Golon, Natalia Smolarek-Kołecka, Krystyna Rożek-Piechura, Paulina Okrzymowska, Beata Pi, Radosław Słopień   +5 more
core   +1 more source

Anatomy and variation in the paraphyletic Mosasaurus lemonnieri assemblage from the Craie phosphatée de ciply, Belgium

The Anatomical Record, EarlyView.
Abstract Nineteenth century excavations of the Ciply‐Malogne Phosphatic Chalk Formation in Hainaut, Belgium, yielded over 50 partial mosasaur skeletons, the majority of which were referred to the species Mosasaurus lemonnieri Dollo, 1889. In the years since, this taxon has experienced a complicated taxonomic history, and its exceptional hypodigm has ...
Henry S. Sharpe, Hallie P. Street‐Sampson, Takuya Konishi, Michael W. Caldwell   +3 more
wiley   +1 more source

Pelvic floor dysfunction, and effects of pregnancy and mode of delivery on pelvic floor

Taiwanese Journal of Obstetrics and Gynecology, 2014
Pelvic floor dysfunction (PFD), although seems to be simple, is a complex process that develops secondary to multifactorial factors. The incidence of PFD is increasing with increasing life expectancy. PFD is a term that refers to a broad range of clinical scenarios, including lower urinary tract excretory and defecation disorders, such as urinary and ...
Murat Bozkurt, Ayşe Ender Yumru, Levent Şahin   +2 more
openaire   +3 more sources

Segmental Arthroscopic Hip Labral Reconstruction Using a Peroneus Longus Allograft

Arthroscopy Techniques, EarlyView.
Abstract Arthroscopic hip labral reconstruction has become an important tool for treating irreparable labral pathology, particularly in the revision setting. Restoration of the acetabular labrum is critical for hip stability, load distribution, and maintenance of the joint suction seal.
Michael T. Kody, Michael B. Banffy
wiley   +1 more source