Results 91 to 100 of about 165,151 (264)

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

Correlation Between Brief Ppain Inventory (BPI) and Pelvic Girdle Questionnaire (PGQ) In Evaluation of Pelvic Girdle in Pregnant Women

مراقبت پرستاری و مامایی ابن سینا, 2020
Introduction: Pain in the lower back and pelvic pain are one of the most common problems in pregnancy. Appropriate and low-cost diagnostic and validated measurements are required.
Farzaneh Rashidi Fakri, Masoumeh Simbar, , Marzieh Saei Ghare Naz, Fahimeh Rashidi fakari   +4 more
doaj  

Maternal Dipyrone Exposure and Risk of Major Congenital Malformations, Adverse Perinatal and Postnatal Outcomes: A Population‐Based Cohort Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pain and fever are common in pregnancy. Dipyrone is widely used in Europe, Latin America, and parts of Asia, but is banned in other countries due to concerns about agranulocytosis. Evidence on its safety in pregnancy remains limited and inconsistent. This study aimed to evaluate whether maternal dipyrone use during the first‐ and third‐trimesters is ...
Itamar Ben Shitrit, Daphna Idan, Ariel Avraham Hasidim, Tal Michael, Amalia Levy, Gali Pariente, Eitan Lunenfeld, Sharon Daniel   +7 more
wiley   +1 more source

Evaluation of embolization for periuterine varices involving chronic pelvic pain secondary to pelvic congestion syndrome

Clinics
OBJECTIVES: To evaluate the clinical response and success rate after periuterine varices embolization in patients with chronic pelvic pain secondary to pelvic congestion syndrome and to report the safety of endovascular treatment and its rate of ...
Flavio Meirelles Siqueira, Lucas Moretti Monsignore, Julio Cesar Rosa-e-Silva, Omero Benedicto Poli-Neto, Luis Henrique de Castro-Afonso, Guilherme Seizem Nakiri, Valdair Francisco Muglia, Daniel Giansante Abud   +7 more
doaj   +1 more source

NMDAR‐antibody encephalitis: Seizure semiology and EEG findings

Epileptic Disorders, EarlyView.
Abstract Background N‐methyl‐D‐aspartate receptor antibody encephalitis (NMDAR‐Ab‐E) is an autoantibody‐mediated disorder, characterized by acute development of neuropsychiatric symptoms, seizures, movement disorders, and autonomic instability. Objectives To describe acute seizure semiology and electroencephalogram (EEG) findings in patients with a ...
Maria Emilia C. Andraus, Bernard Liem, Sidra Aurangzeb, Mkael Symmonds, Adam E. Handel, Sarosh R. Irani, Arjune Sen   +6 more
wiley   +1 more source

Fatalities within seven days after equine standing sedation: A prospective, multicentre study

Equine Veterinary Journal, EarlyView.
Abstract Background Information regarding mortality associated with standing procedures in horses is sparse. Objectives To report data from >12,000 standing sedations. Study Design Confidential, observational, prospective, multicentre, cohort study.
Miguel Gozalo‐Marcilla, José I. Redondo, Polly M. Taylor, Luis Domenech, Javier Doménech, Gordon Mark Johnston, Regula Bettschart‐Wolfensberger   +6 more
wiley   +1 more source

Laser neoureterocystostomy to treat ectopic ureters

Equine Veterinary Journal, EarlyView.
Abstract Background Ureteral ectopia is an uncommon but clinically important congenital abnormality in horses. If left untreated, it can lead to persistent dermatitis, urinary tract infections, and failure to thrive. Surgical correction is necessary, but traditional approaches have produced mixed results with high morbidity.
Caitlin Smith, Eric J. Parente
wiley   +1 more source

Similar locomotor patterns across Quarter Horse disciplines inform lameness assessment

Equine Veterinary Journal, EarlyView.
Abstract Background Lineage‐based selection is central to the Quarter Horse industry and is often justified by the assumption that morphology determines locomotor function. However, objective evidence linking static conformation to discipline‐specific locomotor behaviour under standardised conditions remains limited.
Renata Farinelli de Siqueira, Lavínia Andressa Brito, Isabela Marques de Figueiredo, Ana Clara Rocha dos Santos, Larissa Santos dos Anjos   +4 more
wiley   +1 more source

Pelvic axial rotation in hindlimb lame horses changes after diagnostic analgesia

Equine Veterinary Journal, EarlyView.
Abstract Background Visual assessment of mild to moderate hindlimb lameness has low sensitivity and specificity, potentially leading to flawed diagnostic procedures. Pelvic axial rotation (roll) makes the assessment more complex but is also a potential source of information. Objectives To describe pelvic roll patterns in horses with unilateral hindlimb
Elin Hernlund, Maria Terese Engell, Emma Persson‐Sjödin, Marie Rhodin, Pia Haubro‐Andersen, Anna Byström   +5 more
wiley   +1 more source

Validation of a handheld smartphone markerless method for quantifying thoracolumbar flexion–extension range of motion in horses at trot

Equine Veterinary Journal, EarlyView.
Abstract Background Back pain and poor performance in horses are difficult to assess objectively and thoracolumbar flexion‐extension range of motion (FEROM) is not reliably evaluated by subjective observation alone. A handheld, smartphone‐based markerless computer vision system (RealHorse®; RH) may enable objective clinical and field‐based FEROM ...
Maria Rosendahl Christensen, Jakob Kirkegaard, Katja Berg, Kristian Ringkjær Andresen, Sabrina Skov Hansen, Karsten Key   +5 more
wiley   +1 more source