Results 91 to 100 of about 13,824,933 (347)

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

'Market penetration and pay-back period analysis of a solar photovoltaic system under Indian conditions' [PDF]

open access: yes
The use of pay-back period analysis for economic evaluation of solar photovoltaic (PV) system reinforces the importance of the duration of the system.
Mohan Lal Kolhe
core  

Stability Analysis of a Hybrid Cellular Automaton Model of Cell Colony Growth

open access: yes, 2007
Cell colonies of bacteria, tumour cells and fungi, under nutrient limited growth conditions, exhibit complex branched growth patterns. In order to investigate this phenomenon we present a simple hybrid cellular automaton model of cell colony growth.
A. R. A. Anderson   +6 more
core   +1 more source

Structural Design and Operational Characteristics Analysis of New Vibration Reducing and WOB Increasing Device

open access: yesShiyou jixie, 2018
In highly deviated wells, increased WOB would increase the bending deformation and vibration of the drill string, leading to well inclination, well drift, twist-off of the drill string and premature bit wear.
Fu Chuanhong   +2 more
doaj  

Numerical Calculation of Hydraulic Oscillator

open access: yesShiyou jixie, 2020
The researches on whether the hydraulic oscillator performance can be optimized under certain optimal combination conditions or by changing specific parameters have not yet been carried out, which restricts the further improvement of the tool. To address
Guo Huijuan   +3 more
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Analysis of effects of geological structures in rock driving by TBM [PDF]

open access: yesActa Montanistica Slovaca, 2006
Although mechanical properties belongs to important parameter for the excavation modelling, effect of geological structures on the rock massive fragmentation is often much higher than varying rock properties.
Ľudmila Tréfová
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The role of intermediate layers in the c-axis conductivity of layered superconductors

open access: yes, 1997
A simplified model of c axis transport in the high T_c superconductors is presented. Expressions are found for the c axis optical conductivity, the d.c. resistivity, and the c axis penetration depth.
Atkinson   +7 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

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