Results 101 to 110 of about 13,824,933 (347)

Influence of Drilling Along Pilot Holes on Drilling Performance and Effective Rock Strength

open access: yesApplied Sciences
This study investigates the intricate relationship between bit rock interactions and drilling parameters for multiple-diameter hole drilling scenarios. Two sets of experiments were conducted in the Drilling Technology Laboratory at Memorial University of
Abourawi Alwaar   +4 more
doaj   +1 more source

Interpretation problems of using monitored quantities in a drilling practise [PDF]

open access: yesActa Montanistica Slovaca, 1997
One part of the paper points the ambiguity of the relation between the strength of the disintegrated rock and the actual penetration rate of drilling.
Miklúšová Viera, Bejda Ján
doaj  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Thermally Assisted Penetration and Exclusion of Single Vortex in Mesoscopic Superconductors

open access: yes, 2012
A single vortex overcoming the surface barrier in a mesoscopic superconductor with lateral dimensions of several coherence lengths and thickness of several nanometers provides an ideal platform to study thermal activation of a single vortex.
B. Petukhov   +6 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

On the state of low luminous accreting neutron stars

open access: yes, 2001
Observational appearance of a neutron star in the subsonic propeller state which is a companion of a wind-fed mass-exchange close binary system is discussed.
Arons   +18 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Consumer Learning and Hybrid Vehicle Adoption [PDF]

open access: yes
We study the diffusion of hybrid vehicles among consumers. Using data on sales of 11 different models over seven years, we identify the effect of the penetration rate--total cumulative hybrid sales per capita--on new hybrid purchases.
Heutel, Garth, Muehlegger, Erich
core   +1 more source

Retail Rate Impacts of Distributed Solar: Focus on New England [PDF]

open access: yes, 2017
The Lawrence Berkeley National Laboratory (LBNL) recently issued a study entitled “Putting the Potential Rate Impacts of Distributed Solar into Context,” authored by Galen Barbose.
Martin, Nick, Rábago, Karl R.
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

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