Results 141 to 150 of about 13,824,933 (347)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Field Cone Penetration Tests with Various Penetration Rates - Test Results

, 2011
The test site is located at Nordre Ringgade near the town called Dronninglund in the northern Jutland in Denmark. The site area is relatively flat, and was chosen because it has a size of approximately 3 ha and contains a relatively thick deposit of silty soils.
Poulsen, Rikke, Nielsen, Benjaminn Nordahl, Ibsen, Lars Bo   +2 more
openaire   +1 more source

Evolution of penetration mechanism induced by strain rate effect

EPJ Web of Conferences, 2018
According to the dynamic mechanical properties, in the striking velocity range, the strain rate of the projectile and target caused by penetration can reach 104~106 /s. The strain rate effect increases sharply and then tends to saturation.
Li Gan, Song Chunming, Wang Mingyang
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Analysis on Characteristics of Mixed Traffic Flow with Intelligent Connected Vehicles at Airport Two-Lane Curbside Based on Traffic Characteristics

Aerospace
With the growing adoption of connected and autonomous vehicles (CAVs), their market penetration is expected to rise. This study investigates the mixed traffic flow dynamics of human-driven vehicles (HDVs) and CAVs at airport terminal curbsides.
Xin Chang, Weiping Yang, Yao Tang, Zhe Liu, Zheng Liu   +4 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Determining whether estimated spore release rates for Aspergillus fumigatus are compatible with their measured growth rates in composting systems [PDF]

, 2008
The composting process like other waste management activities has the potential to generate large concentrations of bioaerosols which can be widely dispersed into the surrounding environment.
Fletcher, L.A., Kemp, A.A., Stentiford, E.I.   +2 more
core  

Theoretical aspects for the design software of drive system in the drilling technology

Acta Montanistica Slovaca, 2000
There is defined the function of expence optimization of drilling in a ground massif in the work. It is possible to rewrite the cost optimization formula of Waller and Rowsell to the formula()CBRTHkAERPmA=++ ,whereC - costs related to the current meter ...
Bejda Ján, Miklúšová Viera
doaj