Results 161 to 170 of about 13,824,933 (347)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Nature of the space environment [PDF]

open access: yes
Space environment exploration and chemical composition of cosmic radiation, meteoroid penetration rate, mass and frequency ...
Evvard, J. C.
core   +1 more source

Development and Field Application of the Compound Vibration Drilling Tool

open access: yesShiyou jixie, 2019
To improve the penetration rate of drilling through the hard and soft interbedded formation and soft formation, a compound vibration drilling method is proposed to provide high frequency and low amplitude reciprocating axial vibration load and torsional ...
Zha Chunqing   +4 more
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Factors influence flexibility resistivity and zinc dendrite penetration rate of inorganic separators for alkaline batteries [PDF]

open access: yes
Developmental work resulted in a formulation which can improve the flexibility of the inorganic-organic-type separator for silver-zinc and nickel-zinc alkaline batteries.
Sheibley, D. W.
core   +1 more source

Shale coring technology in Longmaxi formation and Niutitang formation of unconventional shale gas field

open access: yesYouqicang pingjia yu kaifa, 2018
During the drilling process of the shale gas wells, obtaining the high quality core samples is an important prerequisite for the reservoir evaluation. Aiming at the problems such as the long coring footage, the low core recovery and the poor efficiency ...
Cao Huaqing, Gao Changbin
doaj  

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Grain boundary oxidation and fatigue crack growth at elevated temperatures [PDF]

open access: yes
Fatigue crack growth rate at elevated temperatures can be accelerated by grain boundary oxidation. Grain boundary oxidation kinetics and the statistical distribution of grain boundary oxide penetration depth were studied.
Liu, H. W., Oshida, Y.
core   +1 more source

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